NTSR2 Antikörper (AA 176-392)

Produktnummer ABIN7871339

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch NTSR2 in WB, ELISA und FACS. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für NTSR2 Antikörper (AA 176-392) (ABIN7871339)

Target: NTSR2 (Neurotensin Receptor 2 (NTSR2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NTSR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-NTSR2 Antikörper

Bindungsspezifität: AA 176-392

Verwendungszweck: NTSR2 Antibody / Neurotensin receptor type 2

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived mouse NTSR2 recombinant protein (Position: Q176-E392) was used as the immunogen for the NTSR2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the NTSR2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the NTSR2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu NTSR2

Target: NTSR2 (Neurotensin Receptor 2 (NTSR2))

Andere Bezeichnung: NTSR2

Hintergrund: NTSR2 antibody detects Neurotensin receptor type 2, a G protein-coupled receptor (GPCR) that mediates the effects of the neuropeptide neurotensin on neuronal activity, pain modulation, and inflammation. The UniProt recommended name is Neurotensin receptor type 2 (NTSR2). This receptor couples to G proteins to trigger intracellular calcium mobilization and MAPK pathway activation in response to neurotensin binding.

Functionally, NTSR2 antibody identifies a 410-amino-acid seven-transmembrane receptor localized primarily in the central nervous system and peripheral tissues. NTSR2 regulates dopaminergic signaling, nociception, and gastrointestinal motility. It is distinct from NTSR1 in its lower affinity for neurotensin and its unique coupling to Gq and Gi proteins, leading to both excitatory and inhibitory cellular effects.

The NTSR2 gene is located on chromosome 2p25.1 and is highly expressed in the brainstem, hypothalamus, and spinal cord. Peripheral expression in immune cells and smooth muscle contributes to neuroimmune and cardiovascular regulation. NTSR2 activation influences neurotransmitter release, stress response, and vascular tone.

Pathologically, dysregulation of NTSR2 signaling has been associated with pain disorders, schizophrenia, addiction, and cancer progression. Its activation promotes cell migration and survival in certain tumors. Research using NTSR2 antibody supports studies in neuroscience, signal transduction, and receptor pharmacology.

NTSR2 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect GPCRs and neuropeptide receptors. NSJ Bioreagents provides NTSR2 antibody reagents optimized for neurobiology, pharmacology, and signal transduction research.

Structurally, Neurotensin receptor type 2 features seven transmembrane helices typical of GPCRs, an extracellular ligand-binding region, and an intracellular tail that interacts with G proteins and arrestins. This antibody enables investigation of NTSR2's regulatory role in neurotransmission and cellular signaling.

UniProt: P70310