STRIP2 Antikörper (AA 173-507)

Produktnummer ABIN7871274

Der Kaninchen Polyklonal anti-STRIP2 Antikörper wird verwendet zum Nachweis von STRIP2 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IHC, ELISA und FACS.

Kurzübersicht für STRIP2 Antikörper (AA 173-507) (ABIN7871274)

Target: STRIP2 (Striatin Interacting Protein 2 (STRIP2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STRIP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Produktdetails anti-STRIP2 Antikörper

Bindungsspezifität: AA 173-507

Verwendungszweck: STRIP2 Antibody / Striatin-interacting protein 2

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human FAM40B/STRIP2 recombinant protein (Position: H173-Q507) was used as the immunogen for the STRIP2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the STRIP2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the STRIP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu STRIP2

Target: STRIP2 (Striatin Interacting Protein 2 (STRIP2))

Andere Bezeichnung: STRIP2

Hintergrund: STRIP2 antibody detects Striatin-interacting protein 2, a scaffolding protein that functions as a regulatory component of the STRIPAK complex (striatin-interacting phosphatase and kinase complex). STRIP2 integrates protein phosphatase 2A (PP2A) signaling with cytoskeletal organization, cell motility, and developmental signaling. The STRIP2 antibody is used to study PP2A-mediated signal transduction, cell morphology, and organ development.

STRIP2 is encoded by the STRIP2 gene located on human chromosome 7q34. The protein is approximately 92 kilodaltons and shares structural features with STRIP1, including coiled-coil regions that mediate interactions with striatins, kinases, and phosphatases. Through the STRIPAK complex, STRIP2 influences actin dynamics, cell polarity, and cell-cell junction formation.

The STRIP2 antibody identifies a 90-100 kilodalton protein by western blot. STRIP2 functions as a scaffold that couples kinases such as MST1/2 and MAP4Ks to PP2A, thereby controlling phosphorylation-dependent signaling cascades. This coordination regulates tissue growth, planar cell polarity, and morphogenesis.

Loss or mutation of STRIP2 disrupts cytoskeletal organization and leads to abnormal cell migration and tissue formation. In the nervous system, STRIP2 is important for axon outgrowth and synapse development. Studies have linked STRIP2 mutations to congenital myopathies and developmental disorders. In cancer, dysregulated STRIP2 expression has been observed in breast, lung, and prostate tumors, where it may promote invasive behavior.

STRIP2 serves as a crucial adaptor that integrates mechanical and chemical signaling at the cell cortex. Its interactions with the Hippo pathway components connect STRIPAK signaling to growth regulation and organ size control. NSJ Bioreagents provides a validated STRIP2 antibody optimized for its applications facilitating studies of phosphatase regulation, cytoskeletal architecture, and signal coordination.

UniProt: Q9ULQ0