Neurofibromin 1 Antikörper (AA 160-270)

Produktnummer ABIN7871100

Der Maus Monoklonal anti-Neurofibromin 1 Antikörper wird verwendet zum Nachweis von Neurofibromin 1 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IF, IHC (p) und FACS.

Kurzübersicht für Neurofibromin 1 Antikörper (AA 160-270) (ABIN7871100)

Target: Neurofibromin 1 (NF1)

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Neurofibromin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Klon: 4F8B7

Produktdetails anti-Neurofibromin 1 Antikörper

Bindungsspezifität: AA 160-270

Verwendungszweck: NF1 Antibody / Neurofibromin

Aufreinigung: Affinity purified

Immunogen: Recombinant human protein (amino acids R160-Q270) was used as the immunogen for the NF1 antibody.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the NF1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the NF1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Neurofibromin 1

Target: Neurofibromin 1 (NF1)

Andere Bezeichnung: NF1

Hintergrund: Neurofibromin 1 (NF1) is a gene in humans that is located on chromosome 17. This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.

UniProt: P21359

Pathways: cAMP Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity