SEC61B Antikörper (AA 16-96)

Produktnummer ABIN7871093

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SEC61B in WB, ELISA und FACS. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für SEC61B Antikörper (AA 16-96) (ABIN7871093)

Target: SEC61B (Sec61 beta Subunit (SEC61B))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SEC61B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-SEC61B Antikörper

Bindungsspezifität: AA 16-96

Verwendungszweck: SEC61B Antibody / Sec61 subunit beta

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human SEC61B recombinant protein (Position: R16-S96) was used as the immunogen for the SEC61B antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SEC61B antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the SEC61B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu SEC61B

Target: SEC61B (Sec61 beta Subunit (SEC61B))

Andere Bezeichnung: SEC61B

Hintergrund: The SEC61B antibody targets Protein transport protein Sec61 subunit beta, a component of the Sec61 translocon complex encoded by the SEC61B gene. The Sec61 complex mediates the translocation of nascent polypeptides across and into the endoplasmic reticulum (ER) membrane, an essential step in the biosynthesis of secretory and membrane proteins. The SEC61B antibody enables precise detection of this translocon subunit and supports studies of protein targeting, membrane insertion, and ER homeostasis.

Protein transport protein Sec61 subunit beta forms part of the heterotrimeric Sec61 channel, together with the alpha (SEC61A) and gamma (SEC61G) subunits. While the alpha subunit forms the central pore that guides polypeptides through the membrane, the beta subunit participates in channel assembly, stability, and interaction with ribosomes and chaperones. The SEC61B antibody provides a reliable means of detecting this small yet essential component of the translocon, helping researchers understand how it contributes to co-translational protein translocation and membrane integration.

In addition to its structural role, Protein transport protein Sec61 subunit beta is involved in post-translational translocation of proteins and quality control mechanisms that prevent accumulation of misfolded peptides. The SEC61B antibody can be used to monitor ER function under stress conditions, including the unfolded protein response and ER-associated degradation (ERAD). By visualizing SEC61B distribution and expression levels, investigators gain insights into how protein import efficiency correlates with ER capacity and cell health.

The Sec61 complex also functions as a retrotranslocation channel, allowing misfolded proteins to exit the ER for cytosolic degradation by the proteasome. This dual functionality links SEC61B to cellular proteostasis and stress adaptation. The SEC61B antibody is instrumental in exploring these mechanisms and clarifying how perturbations in Sec61 function contribute to diseases such as cystic fibrosis, diabetes, and neurodegeneration. Its detection of Protein transport protein Sec61 subunit beta expression enables both basic and translational research on ER transport regulation.

The SEC61B antibody is suitable for western blotting, immunofluorescence, and immunohistochemistry. It produces distinct ER localization patterns consistent with translocon distribution. NSJ Bioreagents supplies this antibody as a rigorously tested reagent designed for reproducibility across experimental systems. By providing dependable detection of Protein transport protein Sec61 subunit beta, the SEC61B antibody supports molecular research into secretory pathway dynamics, protein biogenesis, and ER function in normal and disease states.

UniProt: P60468

Pathways: Protein targeting to Nucleus