NPTX2 Antikörper (AA 16-431)

Produktnummer ABIN7871079

Der Kaninchen Polyklonal anti-NPTX2 Antikörper wird verwendet zum Nachweis von NPTX2 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IHC und ELISA.

Kurzübersicht für NPTX2 Antikörper (AA 16-431) (ABIN7871079)

Target: NPTX2 (Neuronal Pentraxin II (NPTX2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NPTX2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-NPTX2 Antikörper

Bindungsspezifität: AA 16-431

Verwendungszweck: NPTX2 Antibody / Neuronal pentraxin 2

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human NPTX2 recombinant protein (Position: G16-L431) was used as the immunogen for the NPTX2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the NPTX2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the NPTX2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu NPTX2

Target: NPTX2 (Neuronal Pentraxin II (NPTX2))

Andere Bezeichnung: NPTX2

Hintergrund: NPTX2 antibody detects Neuronal pentraxin-2, a secreted neuronal glycoprotein involved in synaptic plasticity, excitatory synapse formation, and long-term neuronal communication. NPTX2 belongs to the neuronal pentraxin family, which includes NPTX1 and NPTR, proteins that share structural similarities with classical acute-phase pentraxins but function primarily in the central nervous system. The NPTX2 antibody is widely used to study synapse organization, neuronal activity regulation, and neurodegenerative disorders such as Alzheimer's disease.

NPTX2 is encoded by the NPTX2 gene located on human chromosome 7q21.3. The protein is approximately 47 kilodaltons and secreted from presynaptic terminals, where it binds AMPA-type glutamate receptors on postsynaptic neurons. This interaction enhances receptor clustering, synaptic strength, and excitatory transmission. NPTX2 is highly expressed in cortical and hippocampal neurons and plays a key role in activity-dependent synaptic refinement during learning and memory.

The NPTX2 antibody detects a 47 kilodalton band on western blot. In the brain, NPTX2 is upregulated by neuronal activity and acts in concert with NPTX1 and NPTR to regulate synaptic homeostasis. Disruption of NPTX2 expression leads to impaired long-term potentiation and deficits in learning and behavior. Cerebrospinal fluid levels of NPTX2 have been proposed as a biomarker for early-stage neurodegeneration, with reductions correlating to cognitive decline in Alzheimer's and frontotemporal dementia.

At the molecular level, NPTX2 binds to neuronal pentraxin receptor (NPTXR) to form hetero-oligomeric complexes that tether AMPA receptors to the postsynaptic membrane. This complex promotes excitatory synapse stabilization and neurotransmitter signaling efficiency. Dysregulation of this system contributes to excitatory-inhibitory imbalance, a hallmark of several neuropsychiatric and neurodegenerative conditions.

Beyond the nervous system, NPTX2 expression has been observed in pancreatic islets and endocrine tissues, where it may regulate calcium-dependent secretion. NSJ Bioreagents provides a validated NPTX2 antibody optimized for western blot and immunohistochemistry, supporting research into neuronal plasticity, receptor clustering, and disease-related synaptic dysfunction.

UniProt: P47972