BAI1 Antikörper (AA 1537-1567)

Produktnummer ABIN7870991

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch BAI1 in WB, IHC (p) und FACS. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für BAI1 Antikörper (AA 1537-1567) (ABIN7870991)

Target: BAI1 (Brain-Specific Angiogenesis Inhibitor 1 (BAI1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BAI1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Produktdetails anti-BAI1 Antikörper

Bindungsspezifität: AA 1537-1567

Verwendungszweck: Brain-specific angiogenesis inhibitor 1 Antibody / BAI1

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 1537-1567 from the human protein was used as the immunogen for the Brain-specific angiogenesis inhibitor 1 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the Brain-specific angiogenesis inhibitor 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Brain-specific angiogenesis inhibitor 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu BAI1

Target: BAI1 (Brain-Specific Angiogenesis Inhibitor 1 (BAI1))

Andere Bezeichnung: Brain-specific angiogenesis inhibitor 1

Hintergrund: Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas.

UniProt: O14514

Pathways: p53 Signalweg