GBX2 Antikörper (AA 150-350)

Produktnummer ABIN7870925

Dieser Maus Monoklonal Antikörper detektiert spezifisch GBX2 in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für GBX2 Antikörper (AA 150-350) (ABIN7870925)

Target: GBX2 (Gastrulation Brain Homeo Box 2 (GBX2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GBX2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: GBX2-7235

Produktdetails anti-GBX2 Antikörper

Bindungsspezifität: AA 150-350

Verwendungszweck: GBX2 Antibody / Gastrulation Brain Homeobox 2

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 150-350) from the human protein was used as the immunogen for the GBX2 antibody.

Isotyp: IgG2, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the GBX2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the GBX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu GBX2

Target: GBX2 (Gastrulation Brain Homeo Box 2 (GBX2))

Andere Bezeichnung: GBX2

Hintergrund: The isthmic organizer signals at the mid/hindbrain boundary (MHB) regulate the development and differentiation of the vertebrate caudal midbrain and the anterior hindbrain. The MHB forms at the boundary of expression between homeobox genes GBX2 and OTX2. GBX2 and OTX2 play distinct, essential roles in MHB positioning and development. During development, the GBX2 gene is expressed in the anterior hindbrain. Specifically, GBX2 negatively regulates OTX2 expression along the anterior-posterior axis, GBX2- mutants demonstrate an expanded OTX2 domain. During development, the GBX2 gene is expressed in the anterior hindbrain. GBX2 is expressed in the adult brain, spleen and female genital tract. The GBX2 gene is overexpressed in human prostate cancer cell lines (TSU-prl, PC3, DU145 and LNCaP). Furthermore, downregulation of GBX2 expression restricts tumorigenicity in human prostate cancer cell lines, which suggests that GBX2 expression may be required for growth of malignant prostate cells.

UniProt: P52951

Pathways: Dopaminergic Neurogenesis