Transgelin Antikörper (AA 15-170)

Produktnummer ABIN7870782

Der Kaninchen Polyklonal anti-Transgelin Antikörper wird verwendet zum Nachweis von Transgelin in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA, FACS, IHC (p) und IF.

Kurzübersicht für Transgelin Antikörper (AA 15-170) (ABIN7870782)

Target: Transgelin (TAGLN)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Transgelin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Produktdetails anti-Transgelin Antikörper

Bindungsspezifität: AA 15-170

Verwendungszweck: TAGLN Antibody / Transgelin / SM22 alpha

Aufreinigung: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids Q15-E170) was used at the immunogen for the TAGLN antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TAGLN antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the TAGLN antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Transgelin

Target: Transgelin (TAGLN)

Andere Bezeichnung: TAGLN

Hintergrund: Transgelin, also known as SM22 alpha, is a protein that in humans is encoded by the TAGLN gene. This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization.

UniProt: Q01995