Queuine tRNA-Ribosyltransferase Accessory Subunit 2 (QTRT2) (AA 142-386) Antikörper

Produktnummer ABIN7870690

Der Kaninchen Polyklonal anti-Queuine tRNA-Ribosyltransferase Accessory Subunit 2 Antikörper (ABIN7870690) detektiert spezifisch Queuine tRNA-Ribosyltransferase Accessory Subunit 2 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Queuine tRNA-Ribosyltransferase Accessory Subunit 2 (QTRT2) (AA 142-386) Antikörper (ABIN7870690)

Target: Queuine tRNA-Ribosyltransferase Accessory Subunit 2 (QTRT2)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails

Bindungsspezifität: AA 142-386

Verwendungszweck: QTRT2 Antibody / Queuine tRNA-ribosyltransferase subunit 2

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human QTRT2 recombinant protein (Position: Q142-H386) was used as the immunogen for the QTRT2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the QTRT2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the QTRT2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Antigendetails

Target: Queuine tRNA-Ribosyltransferase Accessory Subunit 2 (QTRT2)

Andere Bezeichnung: QTRT2

Hintergrund: QTRT2 antibody detects Queuine tRNA-ribosyltransferase subunit 2, encoded by the QTRT2 gene on chromosome 6p25.1. QTRT2 antibody is widely used in RNA modification, translation, and metabolism research. QTRT2 partners with QTRT1 to form the heterodimeric tRNA-guanine transglycosylase complex that catalyzes incorporation of queuine into the anticodon wobble position of tRNAs. This modification enhances translation accuracy and efficiency.

Structurally, QTRT2 is a ~47 kDa protein that shares homology with QTRT1 but lacks catalytic residues. Instead, QTRT2 functions as a structural subunit that stabilizes the heterodimer and facilitates substrate recognition. QTRT2 localizes to the cytoplasm where tRNA modification occurs. It is conserved across eukaryotes, reflecting its fundamental role in translation regulation.

Functionally, QTRT2 supports tRNA modification that improves translational fidelity and codon-anticodon interactions. Queuine modification affects protein synthesis rates, cellular stress responses, and adaptation to nutrient availability. Researchers use QTRT2 antibody to investigate RNA modifications, translation quality control, and metabolic regulation.

Clinically, defects in queuine modification have been associated with cancer, neurodevelopmental disorders, and infection. Altered expression of QTRT2 has been reported in some tumors, suggesting a role in metabolic reprogramming and growth. Because RNA modifications are emerging therapeutic targets, QTRT2 is under active investigation. NSJ Bioreagents provides QTRT2 antibody to support RNA biology and translational control research.

Experimentally, QTRT2 antibody is applied in western blotting to detect the ~47 kDa protein, in immunofluorescence microscopy to study cytoplasmic localization, and in immunoprecipitation to analyze QTRT1-QTRT2 complexes. Functional assays combining QTRT2 antibody with RNA analysis confirm its role in tRNA modification.

UniProt: Q9H974