FDFT1 Antikörper (AA 140-170)

Produktnummer ABIN7870661

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch FDFT1 in WB und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für FDFT1 Antikörper (AA 140-170) (ABIN7870661)

Target: FDFT1 (Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FDFT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-FDFT1 Antikörper

Bindungsspezifität: AA 140-170

Verwendungszweck: Squalene synthase Antibody / SQS / FDFT1

Aufreinigung: Purified

Immunogen: A portion of amino acids 140-170 from the human protein was used as the immunogen for the Squalene synthase antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the Squalene synthase antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Squalene synthase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu FDFT1

Target: FDFT1 (Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1))

Andere Bezeichnung: Squalene synthase

Hintergrund: FDFT1 / Squalene synthase catalyzes the first step in the cholesterol biosynthetic pathway, the conversion of trans-farnesyldiphosphate to squalene. The loss of promoter activity and response to sterols for FDFT1 is localized to a 69-bp section positioned 131 bp 5-prime to the transcription start site. Sequence analysis of this region shows that it contains a sterol regulatory element-1 (SRE1) previously identified in other sterol regulated genes and 2 putative NF1 binding sites.

UniProt: P37268

Pathways: Regulation of Lipid Metabolism by PPARalpha