HAS2 Antikörper (AA 138-166)

Produktnummer ABIN7870582

Der Kaninchen Polyklonal anti-HAS2 Antikörper (ABIN7870582) detektiert spezifisch HAS2 in WB, FACS und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für HAS2 Antikörper (AA 138-166) (ABIN7870582)

Target: HAS2 (Hyaluronan Synthase 2 (HAS2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HAS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-HAS2 Antikörper

Bindungsspezifität: AA 138-166

Verwendungszweck: Hyaluronan synthase 2 Antibody / HAS2

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 138-166 from the human protein was used as the immunogen for the Hyaluronan synthase 2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the Hyaluronan synthase 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Hyaluronan synthase 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu HAS2

Target: HAS2 (Hyaluronan Synthase 2 (HAS2))

Andere Bezeichnung: Hyaluronan synthase 2

Hintergrund: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.

UniProt: Q92819

Pathways: Glycosaminoglycan Metabolic Process