Neurogenin 3 Antikörper (AA 137-214)

Produktnummer ABIN7870569

Der Kaninchen Polyklonal anti-Neurogenin 3 Antikörper wird verwendet zum Nachweis von Neurogenin 3 in Proben von Human und Maus. Er wurde validiert für WB, ELISA und FACS.

Kurzübersicht für Neurogenin 3 Antikörper (AA 137-214) (ABIN7870569)

Target: Neurogenin 3 (NEUROG3)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Neurogenin 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-Neurogenin 3 Antikörper

Bindungsspezifität: AA 137-214

Verwendungszweck: NEUROG3 Antibody / Neurogenin 3

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human NEUROG3 recombinant protein (Position: Q137-L214) was used as the immunogen for the NEUROG3 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the NEUROG3 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the NEUROG3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Neurogenin 3

Target: Neurogenin 3 (NEUROG3)

Andere Bezeichnung: NEUROG3

Hintergrund: NEUROG3 antibody detects Neurogenin-3, encoded by the NEUROG3 gene. Neurogenin-3 is a basic helix-loop-helix transcription factor that plays a central role in the development of endocrine cells in the pancreas and intestine. NEUROG3 antibody provides researchers with a highly specific reagent for studying pancreatic development, endocrine lineage specification, and diabetes biology.

Neurogenin-3 regulates transcriptional networks that guide progenitor cells toward endocrine fates. Research using NEUROG3 antibody has shown that it activates genes required for insulin, glucagon, somatostatin, and pancreatic polypeptide production. In the intestine, it directs progenitors to form enteroendocrine cells, which secrete hormones critical for digestion and energy homeostasis. These findings emphasize its role as a master regulator of endocrine differentiation.

Studies with NEUROG3 antibody have revealed that mutations in NEUROG3 cause neonatal diabetes and congenital malabsorptive diarrhea. These conditions reflect failure of endocrine cell differentiation, leading to severe metabolic and gastrointestinal dysfunction. This demonstrates that Neurogenin-3 is indispensable for human development.

Beyond congenital disorders, research using NEUROG3 antibody has highlighted its role in regenerative biology. Activation of Neurogenin-3 in adult progenitors can stimulate endocrine differentiation, suggesting therapeutic strategies for diabetes through beta-cell regeneration. These findings expand the relevance of NEUROG3 from development to regenerative medicine.

NEUROG3 is also implicated in cancer. Abnormal expression has been detected in gastrointestinal tumors, where it may influence tumor differentiation. Research using NEUROG3 antibody continues to explore how developmental transcription factors become repurposed in oncogenesis.

NEUROG3 antibody is widely used in immunohistochemistry, western blotting, and immunofluorescence. Immunohistochemistry highlights endocrine progenitors in pancreatic tissue, western blotting quantifies protein levels in development and disease, and immunofluorescence demonstrates nuclear localization. These applications make NEUROG3 antibody indispensable in developmental biology and disease research.

By supplying validated NEUROG3 antibody reagents, NSJ Bioreagents supports studies into pancreatic and intestinal biology, diabetes, and cancer. Detection of Neurogenin-3 provides researchers with insight into how transcription factors regulate lineage specification and disease.

UniProt: Q9Y4Z2