Erythrocyte Ankyrin Antikörper (AA 1300-1844)

Produktnummer ABIN7870499

Dieser Maus Monoklonal Antikörper detektiert spezifisch Erythrocyte Ankyrin in WB und FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Erythrocyte Ankyrin Antikörper (AA 1300-1844) (ABIN7870499)

Target: Erythrocyte Ankyrin (ANK1) (Ankyrin 1, Erythrocytic (ANK1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Erythrocyte Ankyrin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Klon: 5H2E8

Produktdetails anti-Erythrocyte Ankyrin Antikörper

Bindungsspezifität: AA 1300-1844

Verwendungszweck: ANK1 Antibody / Erythrocyte Ankyrin / Ankyrin-1

Aufreinigung: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids N1300-Q1844) was used as the immunogen for the ANK1 antibody.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the ANK1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the ANK1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Erythrocyte Ankyrin

Target: Erythrocyte Ankyrin (ANK1) (Ankyrin 1, Erythrocytic (ANK1))

Andere Bezeichnung: ANK1

Hintergrund: Ankyrin 1, erythrocytic, also known as ANK1, is a protein that in humans is encoded by the ANK1 gene. Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats, a central region with a highly conserved spectrin binding domain, and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified.

UniProt: P16157

Pathways: Synaptic Membrane