STIL Antikörper (AA 13-1287)

Produktnummer ABIN7870455

Der Kaninchen Polyklonal anti-STIL Antikörper wird verwendet zum Nachweis von STIL in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA, IHC (p) und FACS.

Kurzübersicht für STIL Antikörper (AA 13-1287) (ABIN7870455)

Target: STIL (SCL/TAL1 Interrupting Locus (STIL))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STIL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Produktdetails anti-STIL Antikörper

Bindungsspezifität: AA 13-1287

Verwendungszweck: STIL Antibody / SIL / SCL-interrupting locus protein

Aufreinigung: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids N13-F1287) was used as the immunogen for the STIL antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the STIL antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the STIL antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu STIL

Target: STIL (SCL/TAL1 Interrupting Locus (STIL))

Andere Bezeichnung: STIL

Hintergrund: SCL-interrupting locus protein is a protein that in humans is encoded by the STIL gene. This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene.

UniProt: Q15468

Pathways: Tube Formation