TTC39B Antikörper (AA 129-682)

Produktnummer ABIN7870445

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TTC39B in WB, ELISA und FACS. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für TTC39B Antikörper (AA 129-682) (ABIN7870445)

Target: TTC39B (Tetratricopeptide Repeat Domain 39B (TTC39B))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TTC39B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-TTC39B Antikörper

Bindungsspezifität: AA 129-682

Verwendungszweck: TTC39B Antibody / C9orf52

Aufreinigung: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids K129-D682) was used as the immunogen for the TTC39B antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TTC39B antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the TTC39B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu TTC39B

Target: TTC39B (Tetratricopeptide Repeat Domain 39B (TTC39B))

Andere Bezeichnung: TTC39B

Hintergrund: Tetratricopeptide repeat protein 39B is a protein that in humans is encoded by the TTC39B gene. TTC39B protein contains two TPR repeats (aa 39 3-426 and 626 -659). TCC39B protein is the product of a high density lipoprotein (HDL) gene that promotes the ubiquitination and degradation of liver X receptor (LXR). TTC39B null or deficient mice challenged with high fat/cholesterol/bile salt diet exhibit increased LX R protein and target gene expression. TTC39B deficiency is reported to stabilize LXR by reducing its polyubiquitination and proteasomal degradation. Hence it reduces the incidence of atherosclerosis and steatohepatitis. TTC39B deficiency mice display higher levels of HDL and Apoplipoprotein A-1 and lower levels of hepatic triglyceride synthesis.However it does not affect glucose tolerance or hepatic gluconeogenesis.

UniProt: Q5VTQ0