MMP20 Antikörper (AA 124-405)

Produktnummer ABIN7870366

Der Kaninchen Polyklonal anti-MMP20 Antikörper (ABIN7870366) detektiert spezifisch MMP20 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für MMP20 Antikörper (AA 124-405) (ABIN7870366)

Target: MMP20 (Matrix Metalloproteinase 20 (MMP20))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MMP20 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-MMP20 Antikörper

Bindungsspezifität: AA 124-405

Verwendungszweck: MMP20 Antibody / Matrix metalloproteinase 20

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human MMP20 recombinant protein (Position: Y124-K405) was used as the immunogen for the MMP20 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the MMP20 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the MMP20 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu MMP20

Target: MMP20 (Matrix Metalloproteinase 20 (MMP20))

Andere Bezeichnung: MMP20

Hintergrund: MMP20 antibody detects Matrix metalloproteinase-20, an extracellular endopeptidase that degrades enamel matrix proteins during tooth development. The UniProt recommended name is Matrix metalloproteinase-20 (MMP20). Also known as enamelysin, this enzyme belongs to the matrix metalloproteinase family responsible for remodeling extracellular matrix components during morphogenesis and tissue repair.

Functionally, MMP20 antibody identifies a 483-amino-acid secreted zinc-dependent protease synthesized as a zymogen that is activated by propeptide cleavage. MMP20 is specifically expressed in ameloblasts and odontoblasts, where it cleaves amelogenin, ameloblastin, and enamelin to enable proper enamel mineralization and organization.

The MMP20 gene is located on chromosome 11q22.2 and exhibits tissue-specific expression limited primarily to developing teeth. Its enzymatic activity contributes to normal enamel formation and maturation during odontogenesis.

Pathologically, mutations in MMP20 cause autosomal recessive amelogenesis imperfecta, a disorder characterized by defective enamel formation and tooth fragility. Altered MMP20 expression has also been implicated in oral cancer and tissue invasion. Research using MMP20 antibody supports studies in dental biology, extracellular matrix remodeling, and developmental biochemistry.

MMP20 antibody is validated for western blotting, immunohistochemistry, and ELISA to detect matrix-degrading enzymes. NSJ Bioreagents provides MMP20 antibody reagents optimized for dental development, tissue remodeling, and protease regulation research.

Structurally, Matrix metalloproteinase-20 features a catalytic zinc-binding domain and a hemopexin-like domain responsible for substrate recognition. This antibody enables investigation of MMP20's function in enamel formation and extracellular matrix turnover.

UniProt: O60882