SAMD9L Antikörper (AA 1223-1557)

Produktnummer ABIN7870343

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SAMD9L in WB, IHC, ELISA, FACS und IF. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für SAMD9L Antikörper (AA 1223-1557) (ABIN7870343)

Target: SAMD9L (Sterile alpha Motif Domain Containing 9-Like (SAMD9L))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SAMD9L Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF)

Produktdetails anti-SAMD9L Antikörper

Bindungsspezifität: AA 1223-1557

Verwendungszweck: SAMD9L Antibody / Sterile alpha motif domain-containing protein 9-like

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human SAMD9L recombinant protein (Position: L1223-R1557) was used as the immunogen for the SAMD9L antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SAMD9L antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the SAMD9L antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu SAMD9L

Target: SAMD9L (Sterile alpha Motif Domain Containing 9-Like (SAMD9L))

Andere Bezeichnung: SAMD9L

Hintergrund: SAMD9L antibody recognizes Sterile alpha motif domain-containing protein 9-like, encoded by the SAMD9L gene on chromosome 7q21.2. This protein belongs to a family of interferon-inducible proteins involved in innate immunity, cell proliferation regulation, and antiviral defense. SAMD9L contains a sterile alpha motif (SAM) domain that facilitates protein-protein interactions important for cellular signaling and homeostasis. Functional studies have demonstrated that SAMD9L suppresses cell growth and exerts antiviral activity by restricting viral replication within host cells. Pathogenic mutations in SAMD9L have been associated with myelodysplastic syndromes, ataxia-pancytopenia syndrome, and bone marrow failure. Germline mutations can predispose individuals to hematologic malignancies by impairing normal hematopoiesis. Somatic alterations and copy number changes in SAMD9L are also detected in myeloid neoplasms, suggesting a tumor suppressor function. The protein has also been studied in relation to interferon signaling, with increased expression observed following viral infection or inflammatory stimuli. The study of SAMD9L is important for understanding both immune defense and cancer biology. In cellular models, overexpression of SAMD9L inhibits cell proliferation, while knockdown promotes unchecked cell growth, reinforcing its tumor suppressive role. Additionally, SAMD9L mutations contribute to syndromes marked by cerebellar ataxia, pancytopenia, and predisposition to leukemia. This dual role in host defense and growth suppression underscores its biomedical importance. Tools such as SAMD9L antibody are essential for mapping protein expression in bone marrow, peripheral blood, and disease models, and for validating mechanistic insights into immune response pathways. SAMD9L antibodies have been used in western blot and immunohistochemical assays to detect expression changes in patient samples and experimental systems. The ability to track expression changes during interferon treatment or viral infection provides a window into its dynamic role in host-pathogen interactions. Given its links to immune defense and hematological disease, SAMD9L remains an active area of translational research, with implications for both diagnostic and therapeutic strategies.

UniProt: Q8IVG5