HDC Antikörper (AA 12-662)

Produktnummer ABIN7870302

Der Kaninchen Polyklonal anti-HDC Antikörper wird verwendet zum Nachweis von HDC in Proben von Human und Maus. Er wurde validiert für WB, ELISA und IHC (p).

Kurzübersicht für HDC Antikörper (AA 12-662) (ABIN7870302)

Target: HDC (Histidine Decarboxylase (HDC))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HDC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-HDC Antikörper

Bindungsspezifität: AA 12-662

Verwendungszweck: Histidine decarboxylase Antibody / HDC

Aufreinigung: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids R12-V662) was used as the immunogen for the Histidine decarboxylase antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Histidine decarboxylase antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Histidine decarboxylase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu HDC

Target: HDC (Histidine Decarboxylase (HDC))

Andere Bezeichnung: Histidine decarboxylase

Hintergrund: HDC (Histidine decarboxylase) is the enzyme that catalyzes the reaction that produces histamine from histidine with the help of vitamin B6. The HDC gene is mapped on 15q21.2. The deduced 662-amino acid protein has a molecular mass of 74,148 Da. The gene contains 12 exons spanning approximately 24 kb. The biogenic amine histamine is an important modulator of numerous physiologic processes, including neurotransmission, gastric acid secretion, and smooth muscle tone. The biosynthesis of histamine from histidine is catalyzed by the enzyme L-histidine decarboxylase. This homodimeric enzyme is a pyridoxal phosphate(PLP)-dependent decarboxylase and is highly specific for its histidine substrate. Ercan-Sencicek et al. noted that animal studies had shown that lack of Hdc in mice results in increased locomotor and stereotypic behaviors, as well as increased anxiety.

UniProt: P19113