TCTN1 Antikörper (AA 118-470)

Produktnummer ABIN7870264

Der Kaninchen Polyklonal anti-TCTN1 Antikörper (ABIN7870264) detektiert spezifisch TCTN1 in WB, ELISA, IHC und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Ratte, Human und Maus.

Kurzübersicht für TCTN1 Antikörper (AA 118-470) (ABIN7870264)

Target: TCTN1 (Tectonic Family Member 1 (TCTN1))

Reaktivität: Ratte, Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TCTN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Produktdetails anti-TCTN1 Antikörper

Bindungsspezifität: AA 118-470

Verwendungszweck: TCTN1 Antibody / Tectonic 1

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human TCTN1 recombinant protein (Position: Q118-Y470) was used as the immunogen for the TCTN1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TCTN1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the TCTN1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu TCTN1

Target: TCTN1 (Tectonic Family Member 1 (TCTN1))

Andere Bezeichnung: TCTN1

Hintergrund: TCTN1 antibody detects Tectonic-1, a membrane-associated protein essential for ciliogenesis and Hedgehog signaling. The UniProt recommended name is Tectonic-1 (TCTN1). This protein localizes to the ciliary transition zone, where it participates in the formation and maintenance of the primary cilium, a sensory organelle crucial for signal transduction during embryonic development and tissue patterning.

Functionally, TCTN1 antibody identifies a 765-amino-acid protein that interacts with other tectonic complex components such as TCTN2, TCTN3, and MKS1. TCTN1 regulates protein trafficking into the cilium and ensures the proper localization of signaling receptors, including those of the Hedgehog pathway. It is indispensable for normal morphogenesis and neural tube patterning.

The TCTN1 gene is located on chromosome 12q24.11 and is expressed in ciliated cells throughout various tissues, including brain, kidney, and retina. Its activity maintains ciliary structure and mediates signal coordination during development and organogenesis.

Pathologically, mutations in TCTN1 lead to ciliopathies such as Joubert and Meckel-Gruber syndromes, which are characterized by developmental defects in the brain, kidneys, and eyes. Dysfunction of TCTN1 disrupts ciliary signaling, resulting in structural malformations and impaired embryonic patterning. Research using TCTN1 antibody supports studies in ciliary biology, developmental signaling, and ciliopathy mechanisms.

TCTN1 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect ciliary transition zone proteins. NSJ Bioreagents provides TCTN1 antibody reagents optimized for developmental biology, signal transduction, and structural cell biology research.

Structurally, Tectonic-1 contains multiple coiled-coil regions and a C-terminal transmembrane domain that anchor it to the ciliary membrane. This antibody enables investigation of TCTN1's function in ciliogenesis and Hedgehog pathway regulation.

UniProt: Q2MV58

Pathways: Tube Formation