Mast Cell Tryptase Antikörper (AA 115-233)

Produktnummer ABIN7870202

Dieser Maus Monoklonal Antikörper detektiert spezifisch Mast Cell Tryptase in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Mast Cell Tryptase Antikörper (AA 115-233) (ABIN7870202)

Target: Mast Cell Tryptase

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Mast Cell Tryptase Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: TPSAB1-1963

Produktdetails anti-Mast Cell Tryptase Antikörper

Bindungsspezifität: AA 115-233

Verwendungszweck: Mast Cell Tryptase Antibody / TPSAB1

Aufreinigung: Protein G affinity chromatography

Immunogen: A portion of amino acids 115-233 from the human protein was used as the immunogen for this TPSAB1 antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Mast Cell Tryptase antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Mast Cell Tryptase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu Mast Cell Tryptase

Target: Mast Cell Tryptase

Hintergrund: Tryptases comprise a family of trypsin-like serine proteases (peptidase family S1). Tryptases are stored in mast cell secretory granules and basophils. Mast cells are connective tissue cells derived from blood-forming tissues that line arterial walls and secrete substances, which mediate inflammatory and immune responses. Tryptases are released into the extracellular environment and are resistant to all known endogenous proteinase inhibitors. This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type. Human mast cell tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation. Mastocytosis is a term collectively used for a group of disorders in which there is abnormal accumulation of mast cells in one or multiple organs. Anti-tryptase, combined with anti-CD2, anti-CD25, and anti-CD117, can be useful in identifying reactive mast cell hyperplasia, myelogenous neoplasms, mast cell leukemia, and mastocytosis.

UniProt: Q15661