NCDN Antikörper (AA 114-426)

Produktnummer ABIN7870192

Der Kaninchen Polyklonal anti-NCDN Antikörper (ABIN7870192) detektiert spezifisch NCDN in WB, ELISA, IHC, IF und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte und Maus.

Kurzübersicht für NCDN Antikörper (AA 114-426) (ABIN7870192)

Target: NCDN (Neurochondrin (NCDN))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NCDN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-NCDN Antikörper

Bindungsspezifität: AA 114-426

Verwendungszweck: NCDN Antibody / Neurochondrin

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human NCDN recombinant protein (Position: F114-K426) was used as the immunogen for the NCDN antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the NCDN antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the NCDN antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu NCDN

Target: NCDN (Neurochondrin (NCDN))

Andere Bezeichnung: NCDN

Hintergrund: NCDN antibody recognizes Neurochondrin, a cytoplasmic protein that modulates neuronal differentiation, receptor signaling, and synaptic plasticity. Neurochondrin is widely expressed in the central nervous system, including the hippocampus, cerebellum, and cerebral cortex, where it influences long-term synaptic potentiation and memory formation. The protein functions as a negative regulator of metabotropic glutamate receptor 5 (mGluR5) signaling by interacting with G-protein coupled receptor complexes, thereby controlling calcium homeostasis and dendritic spine development. During neural differentiation, Neurochondrin promotes neurite outgrowth and cytoskeletal organization, making it a key factor in neuronal morphogenesis.

Neurochondrin, encoded by the NCDN gene on chromosome 12q13.3, is approximately 79 kilodaltons in size and highly conserved among vertebrates. It is enriched in postmitotic neurons and functions as a scaffold linking cell surface receptors with intracellular signaling cascades. The protein associates with calmodulin and modulates calcium-dependent processes critical for neuronal excitability. In animal models, loss of NCDN expression disrupts spatial learning and synaptic signaling, underscoring its role in cognitive function. Furthermore, mutations or altered expression of NCDN have been linked to neurodevelopmental disorders and schizophrenia, highlighting its importance in brain health and disease.

The NCDN antibody is used to study neuronal signaling and synaptic regulation in both developmental and disease contexts. In research applications, it detects Neurochondrin by western blot, immunocytochemistry, and immunohistochemistry. The antibody identifies distinct cytoplasmic localization in neurons, particularly within dendritic arbors, consistent with its role in synaptic modulation. Beyond the brain, Neurochondrin expression has been detected in cardiac and endocrine tissues, suggesting additional regulatory functions outside the nervous system. Proteomic studies have also linked NCDN to cytoskeletal organization and intracellular trafficking networks.

Through its interactions with signaling proteins such as CaMKII and GRM5, Neurochondrin integrates receptor activation with downstream pathways influencing synaptic plasticity and learning. Its modulation of calcium signaling provides a mechanistic link between neurotransmission and neuronal adaptation. Because of these diverse regulatory roles, the NCDN antibody is a valuable reagent for exploring molecular mechanisms underlying cognition, synaptic remodeling, and psychiatric disorders. NSJ Bioreagents offers this antibody validated for high specificity and sensitivity in neural tissue applications.

UniProt: Q9UBB6