POLG Antikörper (AA 1120-1148)

Produktnummer ABIN7870144

Der Kaninchen Polyklonal anti-POLG Antikörper (ABIN7870144) detektiert spezifisch POLG in WB, IHC (p), IF und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für POLG Antikörper (AA 1120-1148) (ABIN7870144)

Target: POLG (Polymerase (DNA Directed), gamma (POLG))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser POLG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-POLG Antikörper

Bindungsspezifität: AA 1120-1148

Verwendungszweck: POLG Antibody

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 1120-1148 from the human protein was used as the immunogen for the POLG antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the POLG antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the POLG antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu POLG

Target: POLG (Polymerase (DNA Directed), gamma (POLG))

Andere Bezeichnung: POLG

Hintergrund: Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.

UniProt: P54098