PDE6A Antikörper (AA 11-237)

Produktnummer ABIN7870070

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PDE6A in WB, ELISA, FACS, IF und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für PDE6A Antikörper (AA 11-237) (ABIN7870070)

Target: PDE6A (phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDE6A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-PDE6A Antikörper

Bindungsspezifität: AA 11-237

Verwendungszweck: PDE6 alpha Antibody / PDE6A

Aufreinigung: Affinity purified

Immunogen: Recombinant human protein (amino acids K11-R237) was used as the immunogen for the PDE6 alpha antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PDE6 alpha antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the PDE6 alpha antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu PDE6A

Target: PDE6A (phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A))

Andere Bezeichnung: PDE6 alpha

Hintergrund: This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.

UniProt: P16499

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction