ALOX5 Antikörper (pSer271) (Biotin)

Produktnummer ABIN743530

This anti-ALOX5 antibody (ABIN743530) is a Rabbit Polyclonal antibody detecting ALOX5 in ELISA, IHC (p), IHC (fro). Suitable for Rat.

Kurzübersicht für ALOX5 Antikörper (pSer271) (Biotin) (ABIN743530)

Target: ALOX5 (Arachidonate 5-Lipoxygenase (ALOX5))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALOX5 Antikörper ist konjugiert mit Biotin

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-ALOX5 Antikörper (Biotin)

Bindungsspezifität: pSer271

Kreuzreaktivität: Ratte

Homologie: Human,Mouse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from rat 5-Lipoxygenase around the phosphorylation site of Ser271

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu ALOX5

Target: ALOX5 (Arachidonate 5-Lipoxygenase (ALOX5))

Andere Bezeichnung: 5-Lipoxygenase

Hintergrund:

Synonyms: 5-lipoxygenase, 5 LO, 5LPG, ALOX 5, ALOX5, Arachidonate 5 lipoxygenase, Arachidonic acid 5 lipoxygenase, Leukotriene A4 synthase, LOG 5, LOG5, MGC163204, LOX5_HUMAN.

Background: This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.

Gen-ID: 240