SLC15A5 Antikörper (AA 10-579)

Produktnummer ABIN7869713

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SLC15A5 in WB und ELISA. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für SLC15A5 Antikörper (AA 10-579) (ABIN7869713)

Target: SLC15A5 (Solute Carrier Family 15, Member 5 (SLC15A5))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLC15A5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-SLC15A5 Antikörper

Bindungsspezifität: AA 10-579

Verwendungszweck: SLC15A5 Antibody / Solute carrier family 15 member 5

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human SLC15A5 recombinant protein (Position: D10-L579) was used as the immunogen for the SLC15A5 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SLC15A5 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the SLC15A5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu SLC15A5

Target: SLC15A5 (Solute Carrier Family 15, Member 5 (SLC15A5))

Andere Bezeichnung: SLC15A5

Hintergrund: SLC15A5 antibody detects Solute carrier family 15 member 5, a member of the proton-coupled oligopeptide transporter family that contributes to peptide transport across cellular membranes. The UniProt recommended name is Solute carrier family 15 member 5 (SLC15A5). This membrane protein is primarily expressed in the brain and functions in the uptake and recycling of small peptides, potentially influencing neuronal signaling and metabolic homeostasis.

Functionally, SLC15A5 antibody identifies a 579-amino-acid transmembrane transporter characterized by multiple hydrophobic segments that form a peptide permeation pathway. While the physiological substrates of SLC15A5 remain under investigation, its sequence homology with other SLC15 family members (such as SLC15A1/PEPT1 and SLC15A2/PEPT2) suggests it operates as a proton-dependent symporter. SLC15A5 likely participates in regulating peptide and amino acid availability in neuronal and glial cells, supporting neurotransmitter synthesis and signaling balance.

The SLC15A5 gene is located on chromosome 12q21.31 and is expressed primarily in the central nervous system, with highest levels observed in cerebellum and hippocampus. Expression is tightly regulated during neural development and may respond to metabolic or synaptic activity changes. In addition to its neuronal role, SLC15A5 expression has been reported in skeletal muscle and testis, indicating potential tissue-specific transport functions.

Pathologically, disruption of SLC15A5 expression has been linked to neurological and psychiatric conditions. Variants in the SLC15A5 locus have been associated with susceptibility to major depressive disorder and cognitive dysfunction. Abnormal transporter activity may affect brain peptide signaling and synaptic communication. Research using SLC15A5 antibody supports studies in membrane transport, neurobiology, and metabolic regulation.

SLC15A5 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect peptide transport proteins. NSJ Bioreagents provides SLC15A5 antibody reagents optimized for studies in neuronal peptide uptake, proton-coupled transport, and solute carrier family biology.

Structurally, Solute carrier family 15 member 5 contains 12 predicted transmembrane helices forming a transporter channel and cytoplasmic domains involved in proton coupling and regulation. Conserved motifs typical of the SLC15 family mediate substrate binding and conformational shifts during the transport cycle. This antibody enables investigation of SLC15A5's role in neuronal physiology, peptide metabolism, and cellular transport processes.

UniProt: A6NIM6