Rekombinanter CSTA Antikörper (AA 1-98)

Produktnummer ABIN7869663

Der Kaninchen Monoklonal anti-CSTA Antikörper wird verwendet zum Nachweis von CSTA in Proben von Human. Er wurde validiert für WB und IHC (p).

Kurzübersicht für Rekombinanter CSTA Antikörper (AA 1-98) (ABIN7869663)

Target: CSTA (Cystatin A (Stefin A) (CSTA))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser CSTA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: CSTA-9087R

Produktdetails anti-CSTA Antikörper

Bindungsspezifität: AA 1-98

Verwendungszweck: Recombinant Cystatin A Antibody / CSTA

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant fragment of human CSTA protein (within amino acids 1-98) was used as the immunogen for the recombinant Cystatin A antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: 1.Optimal dilution of the recombinant Cystatin A antibody should be determined by the researcher.

2. This recombinant Cystatin A antibody was recombinantly expressed in CHO cells.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the recombinant Cystatin A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu CSTA

Target: CSTA (Cystatin A (Stefin A) (CSTA))

Andere Bezeichnung: Cystatin A

Hintergrund: Cystatin A antibody targets Cystatin A, a cytoplasmic cysteine protease inhibitor encoded by the CSTA gene and a member of the type I cystatin family. Cystatin A is also widely known as Stefin A and functions as an endogenous inhibitor of papain-like cysteine proteases, including cathepsins B, H, and L. By regulating intracellular protease activity, Cystatin A plays an essential role in protecting epithelial cells from excessive proteolysis and maintaining tissue integrity.

Cystatin A is predominantly localized in the cytoplasm and is highly expressed in stratified squamous epithelia such as epidermis, oral mucosa, esophagus, and cervix. It is closely associated with epithelial differentiation and keratinization processes, where controlled protease inhibition is required for proper barrier formation. Cystatin A antibody detection is therefore useful for studying epithelial maturation, protease balance, and barrier-related biology.

Functionally, Cystatin A binds tightly to cysteine proteases and suppresses their enzymatic activity, thereby influencing cellular processes including apoptosis, inflammation, and cell migration. Through modulation of cathepsin activity, Cystatin A contributes to controlled protein turnover and cellular homeostasis. CSTA antibody reagents support research into protease-inhibitor networks that are critical for normal epithelial function and stress responses.

Altered expression of Cystatin A has been reported in multiple disease contexts, particularly in epithelial-derived cancers. Reduced or heterogeneous CSTA expression has been associated with increased invasiveness and poor differentiation, while strong expression is often retained in well-differentiated squamous cell carcinomas. Changes in Cystatin A levels have also been linked to inflammatory skin disorders and barrier dysfunction, highlighting its relevance in both cancer biology and dermatological research.

Clone CSTA/9087R is designed to recognize Cystatin A in research applications. Cystatin A antibody reagents are suitable for detecting protein expression and localization in epithelial tissues and tumor samples, supporting investigations into protease regulation, epithelial differentiation, and disease-associated alterations in cysteine protease inhibition.

UniProt: P01040

Pathways: Response to Water Deprivation