Rekombinanter Parvin, beta Antikörper (N-Term)

Produktnummer ABIN7869612

Der Kaninchen Monoklonal anti-Parvin, beta Antikörper wird verwendet zum Nachweis von Parvin, beta in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für Rekombinanter Parvin, beta Antikörper (N-Term) (ABIN7869612)

Target: Parvin, beta (PARVB)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Parvin, beta Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: PARVB-8214R

Produktdetails anti-Parvin, beta Antikörper

Bindungsspezifität: AA 1-91, N-Term

Verwendungszweck: Beta-Parvin Antibody / PARVB

Aufreinigung: Protein A/G affinity

Immunogen: The N-terminal region (residues 1-91) of the human protein was used as the immunogen for the Beta-Parvin antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Beta-Parvin antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Beta-Parvin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu Parvin, beta

Target: Parvin, beta (PARVB)

Andere Bezeichnung: Beta-Parvin

Hintergrund: Beta-parvin, also known as affixin, is a focal adhesion protein belonging to a family of ILKbinding proteins that contain tandem calponin homolog domains. Along with Alpha-parvin, Beta-parvin is one of the most widely researched and characterized members of this family. These two proteins interact with the ILK kinase domain in a way that is mutually exclusive and regulates both the activity of the kinase and actin cytoskeleton adhesion. Studies have shown Beta-parvin to be downregulated within human breast cancer cells, and that its expression may influence the progression of breast cancer (Johnstone, 2008). Additional research indicates a critical role for Beta-parvin in the regulation of cardiac contractility when it is in complex with ILK (Hannigan, 2007).

UniProt: Q9HBI1