LYRM4 Antikörper (AA 1-91)

Produktnummer ABIN7869610

Der Kaninchen Polyklonal anti-LYRM4 Antikörper (ABIN7869610) detektiert spezifisch LYRM4 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für LYRM4 Antikörper (AA 1-91) (ABIN7869610)

Target: LYRM4 (LYR Motif Containing 4 (LYRM4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LYRM4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-LYRM4 Antikörper

Bindungsspezifität: AA 1-91

Verwendungszweck: LYRM4 Antibody / LYR motif-containing protein 4

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human LYRM4 recombinant protein (Position: M1-T91) was used as the immunogen for the LYRM4 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the LYRM4 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the LYRM4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu LYRM4

Target: LYRM4 (LYR Motif Containing 4 (LYRM4))

Andere Bezeichnung: LYRM4

Hintergrund: LYRM4 antibody detects LYR motif-containing protein 4, a mitochondrial scaffold protein essential for assembly of the iron-sulfur (Fe-S) cluster synthesis complex. LYRM4 plays a central role in mitochondrial energy metabolism by stabilizing the cysteine desulfurase NFS1 and facilitating delivery of sulfur to Fe-S cluster acceptor proteins. The LYRM4 antibody is widely used in mitochondrial biology and bioenergetics research to study iron-sulfur assembly, oxidative phosphorylation, and metabolic regulation.

LYRM4 is encoded by the LYRM4 gene located on human chromosome 6p25.1. The protein is approximately 108 amino acids long and contains a conserved LYR motif (Leucine-Tyrosine-Arginine) that mediates protein-protein interactions within mitochondrial assembly complexes. LYRM4 localizes to the mitochondrial matrix, where it forms a complex with NFS1, ISD11, and ACP (acyl carrier protein) to generate Fe-S clusters required for electron transport chain enzymes and metabolic enzymes such as aconitase and succinate dehydrogenase.

The LYRM4 antibody detects a 12 kilodalton band by western blot and shows mitochondrial matrix localization under immunofluorescence. LYRM4 is indispensable for mitochondrial biogenesis and redox balance. Its loss leads to impaired respiratory chain function, reduced ATP generation, and increased oxidative stress. Inherited mutations in LYRM4 cause mitochondrial disorders characterized by lactic acidosis, muscle weakness, and neurodegeneration.

Beyond its structural role in Fe-S cluster biogenesis, LYRM4 participates in metabolic adaptation under hypoxia and nutrient deprivation, regulating Fe-S cluster allocation between metabolic enzymes. It also influences lipoic acid synthesis and coenzyme Q biosynthesis through shared pathways in mitochondrial metabolism. Dysregulation of LYRM4 has been associated with oxidative damage and mitochondrial DNA instability in various pathologies, including Parkinson's disease and metabolic syndrome.

Because LYRM4 integrates iron-sulfur metabolism with mitochondrial energy production, it serves as a fundamental component of cellular respiration and redox regulation. NSJ Bioreagents provides a validated LYRM4 antibody optimized for its applications, supporting research into Fe-S cluster assembly, oxidative metabolism, and mitochondrial disease mechanisms.

UniProt: Q9HD34