TFF1 Antikörper (AA 1-84)

Produktnummer ABIN7869584

Dieser Maus Monoklonal Antikörper detektiert spezifisch TFF1 in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für TFF1 Antikörper (AA 1-84) (ABIN7869584)

Target: TFF1 (Trefoil Factor 1 (TFF1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TFF1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: TFF1-7768

Produktdetails anti-TFF1 Antikörper

Bindungsspezifität: AA 1-84

Verwendungszweck: Estrogen Inducible Protein pS2 Antibody / TFF1 (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1-84) from the human protein was used as the immunogen for the Estrogen Inducible Protein pS2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Estrogen Inducible Protein pS2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Estrogen Inducible Protein pS2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu TFF1

Target: TFF1 (Trefoil Factor 1 (TFF1))

Andere Bezeichnung: Estrogen Inducible Protein pS2

Hintergrund: It recognizes a polypeptide of 6.5 kDa, identified as pS2 estrogen-regulated protein. Its epitope is located in the c-terminus of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60 % of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.

UniProt: P04155

Pathways: EGFR Signaling Pathway