USP5 Antikörper (AA 1-800)

Produktnummer ABIN7869566

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch USP5 in WB, ELISA, IF, IHC (p) und FACS. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für USP5 Antikörper (AA 1-800) (ABIN7869566)

Target: USP5 (Ubiquitin Specific Peptidase 5 (USP5))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Produktdetails anti-USP5 Antikörper

Bindungsspezifität: AA 1-800

Verwendungszweck: USP5 Antibody / Ubiquitin carboxyl-terminal hydrolase 5

Aufreinigung: Antigen affinity purified

Immunogen: Amino acids M1-K800 from the human protein were used as the immunogen for the USP5 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the USP5 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the USP5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu USP5

Target: USP5 (Ubiquitin Specific Peptidase 5 (USP5))

Andere Bezeichnung: USP5

Hintergrund: USP5 (Ubiquitin carboxyl-terminal hydrolase 5) is a member of the deubiquitinating enzyme (DUB) family, which plays a central role in regulating protein stability and turnover by processing ubiquitin chains. USP5 specifically disassembles unanchored polyubiquitin chains into monoubiquitin, maintaining a sufficient pool of free ubiquitin necessary for cellular homeostasis. A USP5 antibody is widely used to study protein degradation, ubiquitin recycling, and regulatory pathways involving the proteasome.

USP5, sometimes referred to as Isopeptidase T, functions in close connection with the ubiquitin-proteasome system, a critical mechanism for protein quality control. By hydrolyzing ubiquitin linkages, it prevents the accumulation of free polyubiquitin chains, which could otherwise interfere with proteasomal activity. Using a USP5 antibody enables researchers to evaluate its expression patterns, subcellular localization, and functional involvement in ubiquitin dynamics.

Dysregulation of USP5 has been linked to several disease processes. Elevated USP5 expression has been associated with tumor progression in cancers such as glioblastoma, colorectal cancer, and pancreatic cancer, where it contributes to cell proliferation and survival. It has also been implicated in neurological disorders due to its role in protein turnover, highlighting its importance in both health and disease. Investigating these roles with a USP5 antibody provides valuable insights into its potential as a biomarker or therapeutic target.

NSJ Bioreagents offers a high-quality USP5 antibody validated for applications including western blot, immunohistochemistry, and immunofluorescence. Selecting a USP5 antibody from NSJ Bioreagents ensures reliable results and reproducibility in studies focused on the ubiquitin-proteasome pathway, cancer biology, and protein regulation.

UniProt: P45974