SP110 Antikörper (AA 1-615)

Produktnummer ABIN7869498

Der Kaninchen Polyklonal anti-SP110 Antikörper wird verwendet zum Nachweis von SP110 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA, IHC und FACS.

Kurzübersicht für SP110 Antikörper (AA 1-615) (ABIN7869498)

Target: SP110 (SP110 Nuclear Body Protein (SP110))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SP110 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Produktdetails anti-SP110 Antikörper

Bindungsspezifität: AA 1-615

Verwendungszweck: SP110 Antibody / SP110 nuclear body protein

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human SP110 recombinant protein (Position: M1-E615) was used as the immunogen for the SP110 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SP110 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the SP110 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu SP110

Target: SP110 (SP110 Nuclear Body Protein (SP110))

Andere Bezeichnung: SP110

Hintergrund: SP110 antibody detects SP110 nuclear body protein, a transcriptional coactivator and nuclear body component involved in immune response regulation and chromatin organization. The UniProt recommended name is SP110 nuclear body protein (SP110). This nuclear protein functions as part of the promyelocytic leukemia (PML) nuclear body complex, participating in transcriptional control, apoptosis, and antiviral defense.

Functionally, SP110 antibody identifies a 688-amino-acid protein that acts as a coactivator for nuclear hormone receptors and NF-kappaB-dependent transcription. SP110 regulates gene expression in macrophages and lymphocytes, enhancing interferon-stimulated gene transcription and pathogen defense. It also contributes to chromatin remodeling and transcriptional repression of inflammatory genes through PML-associated nuclear bodies.

The SP110 gene is located on chromosome 2q37.1 and is highly expressed in hematopoietic tissues. SP110 expression is induced by interferon signaling and pathogen exposure, positioning it as a regulator of innate and adaptive immune responses. Its nuclear localization and coactivator activity support immune system homeostasis and pathogen resistance.

Pathologically, SP110 gene mutations are associated with hepatic veno-occlusive disease with immunodeficiency (VODI), a rare autosomal recessive disorder causing liver failure and impaired immunity. Abnormal expression of SP110 has also been linked to autoimmune conditions and susceptibility to intracellular infections such as tuberculosis. Research with SP110 antibody supports studies in nuclear organization, immune regulation, and transcriptional control.

SP110 antibody is suitable for western blotting, immunofluorescence, and immunohistochemistry to detect nuclear body components and transcriptional cofactors. NSJ Bioreagents offers SP110 antibody reagents validated for use in immunology, transcription, and chromatin regulation research.

Structurally, SP110 contains N-terminal SAND and coiled-coil domains that mediate DNA and protein binding, as well as nuclear localization signals that target it to PML bodies. This antibody enables analysis of SP110's role in transcriptional activation and immune regulation under interferon signaling conditions.

UniProt: Q9HB58