RTKN2 Antikörper (AA 1-572)

Produktnummer ABIN7869483

Der Kaninchen Polyklonal anti-RTKN2 Antikörper wird verwendet zum Nachweis von RTKN2 in Proben von Human, Maus und Ratte. Er wurde validiert für ELISA, WB und FACS.

Kurzübersicht für RTKN2 Antikörper (AA 1-572) (ABIN7869483)

Target: RTKN2 (Rhotekin 2 (RTKN2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RTKN2 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Flow Cytometry (FACS)

Produktdetails anti-RTKN2 Antikörper

Bindungsspezifität: AA 1-572

Verwendungszweck: RTKN2 Antibody / Rhotekin 2

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human RTKN2 recombinant protein (Position: M1-D572) was used as the immunogen for the RTKN2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the RTKN2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the RTKN2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu RTKN2

Target: RTKN2 (Rhotekin 2 (RTKN2))

Andere Bezeichnung: RTKN2

Hintergrund: RTKN2 antibody detects Rhotekin 2, a Rho GTPase effector protein that regulates cytoskeletal dynamics, apoptosis, and immune cell signaling. The UniProt recommended name is Rhotekin 2 (RTKN2). This protein acts as a scaffold for RhoA-mediated signaling pathways that control actin organization, transcriptional activity, and cell survival.

Functionally, RTKN2 antibody identifies a 646-amino-acid cytoplasmic protein containing a Rho-binding domain (RBD) and ankyrin repeats that mediate protein-protein interactions. RTKN2 binds active GTP-bound RhoA to stabilize cytoskeletal structures and prevent apoptotic signaling. It also influences NF-kappaB activation and transcriptional regulation of immune and inflammatory genes. In T lymphocytes, RTKN2 promotes cell survival and proliferation by integrating RhoA and anti-apoptotic signaling pathways.

The RTKN2 gene is located on chromosome 10q21.1 and is highly expressed in lymphoid tissues, testis, and brain. Expression increases during T-cell activation and stress responses, indicating roles in immune signaling and cytoskeletal adaptation. RTKN2 contributes to both structural stability and signaling plasticity within dynamic cellular environments.

Pathologically, RTKN2 has been implicated in cancer and autoimmune disease. Overexpression enhances survival and proliferation of cancer cells through activation of NF-kappaB and suppression of apoptosis, whereas reduced RTKN2 expression may impair lymphocyte function and stress resistance. Research using RTKN2 antibody supports studies in Rho GTPase signaling, cytoskeletal dynamics, and immune cell regulation.

RTKN2 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect Rho effector proteins. NSJ Bioreagents provides RTKN2 antibody reagents optimized for research in signal transduction, apoptosis regulation, and cytoskeletal remodeling.

Structurally, Rhotekin 2 consists of a central RhoA-binding domain, ankyrin repeats, and multiple phosphorylation sites that control its localization and interaction with downstream effectors. Its structure enables binding to GTP-bound RhoA and integration with cell survival pathways. This antibody facilitates analysis of RTKN2's role in Rho-dependent signaling and immune cell function.

UniProt: Q8IZC4