RARS2 Antikörper (AA 1-560)

Produktnummer ABIN7869474

Der Kaninchen Polyklonal anti-RARS2 Antikörper wird verwendet zum Nachweis von RARS2 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA und FACS.

Kurzübersicht für RARS2 Antikörper (AA 1-560) (ABIN7869474)

Target: RARS2 (Arginyl-tRNA Synthetase 2, Mitochondrial (RARS2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RARS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-RARS2 Antikörper

Bindungsspezifität: AA 1-560

Verwendungszweck: RARS2 Antibody / Arginyl-tRNA synthetase 2

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human RARS2 recombinant protein (Position: M1-R560) was used as the immunogen for the RARS2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the RARS2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the RARS2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu RARS2

Target: RARS2 (Arginyl-tRNA Synthetase 2, Mitochondrial (RARS2))

Andere Bezeichnung: RARS2

Hintergrund: RARS2 antibody detects Arginyl-tRNA synthetase 2, mitochondrial, an enzyme that catalyzes the attachment of arginine to its corresponding mitochondrial tRNA during protein synthesis. RARS2 plays a critical role in maintaining mitochondrial translation and respiratory chain function. The RARS2 antibody is used in mitochondrial biology, genetics, and neurodegenerative research to study mitochondrial protein synthesis and energy metabolism.

RARS2 is encoded by the RARS2 gene located on human chromosome 6q16.1. The protein is approximately 580 amino acids long and localizes to the mitochondrial matrix, where it contributes to the translation of 13 essential oxidative phosphorylation (OXPHOS) subunits encoded by mitochondrial DNA. RARS2 functions as part of the aminoacyl-tRNA synthetase family, ensuring fidelity of tRNA charging for mitochondrial translation.

The RARS2 antibody detects a 65 kilodalton protein by western blot and reveals mitochondrial localization under confocal imaging. RARS2 ensures accurate incorporation of arginine during protein synthesis, maintaining the stoichiometry of respiratory chain complexes. Loss of RARS2 activity disrupts mitochondrial protein translation, leading to decreased OXPHOS efficiency and increased oxidative stress.

Mutations in RARS2 cause pontocerebellar hypoplasia type 6, a neurodegenerative disorder characterized by developmental delay, seizures, and cerebellar atrophy. In cellular models, depletion of RARS2 impairs mitochondrial respiration, ATP production, and neuronal viability. Its regulation is closely tied to mitochondrial biogenesis and stress adaptation.

As an essential enzyme for mitochondrial translation and neural health, RARS2 is a valuable model for understanding mitochondrial gene expression and energy homeostasis. NSJ Bioreagents provides a validated RARS2 antibody optimized for its applications, supporting studies in mitochondrial translation, metabolic regulation, and neurodegenerative disease mechanisms.

UniProt: Q5T160