ODZ1/Teneurin 1 Antikörper (AA 1-502)

Produktnummer ABIN7869434

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch ODZ1/Teneurin 1 in ELISA, IF, IHC und FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für ODZ1/Teneurin 1 Antikörper (AA 1-502) (ABIN7869434)

Target: ODZ1/Teneurin 1 (TENM1) (Teneurin Transmembrane Protein 1 (TENM1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ODZ1/Teneurin 1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Produktdetails anti-ODZ1/Teneurin 1 Antikörper

Bindungsspezifität: AA 1-502

Verwendungszweck: TENM1 Antibody / Teneurin 1

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human Teneurin 1/TENM1 recombinant protein (Position: M1-G502) was used as the immunogen for the TENM1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TENM1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the TENM1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu ODZ1/Teneurin 1

Target: ODZ1/Teneurin 1 (TENM1) (Teneurin Transmembrane Protein 1 (TENM1))

Andere Bezeichnung: TENM1

Hintergrund: TENM1 antibody detects Teneurin 1, a large type II transmembrane protein involved in neuronal connectivity, axon guidance, and cell-cell adhesion. Encoded by the TENM1 gene on chromosome Xq25, Teneurin 1 belongs to the teneurin family of developmental regulators characterized by large extracellular domains containing EGF-like and YD-repeat motifs that mediate homophilic and heterophilic interactions. During embryonic development, Teneurin 1 is prominently expressed in the nervous system, particularly in sensory ganglia and the olfactory bulb, where it contributes to the establishment of topographic neuronal maps and synaptic specificity.

Teneurin 1 functions through both its extracellular and intracellular domains. The intracellular region can be proteolytically cleaved and translocated to the nucleus, where it may regulate gene transcription. The extracellular domain mediates adhesion between neurons and their target cells, guiding axons toward correct synaptic partners. Loss of TENM1 disrupts neural circuit formation and has been associated with neurodevelopmental disorders, including intellectual disability and autism spectrum conditions. The TENM1 antibody is a critical tool for investigating axon guidance mechanisms, neuronal differentiation, and cell adhesion processes within the central nervous system.

In addition to its developmental roles, Teneurin 1 contributes to cancer cell adhesion and metastasis. Aberrant expression has been detected in glioblastoma and neuroblastoma, linking TENM1 to oncogenic signaling pathways. The antibody detects both full-length membrane-bound and cleaved intracellular forms, supporting comprehensive study of its signaling functions. Immunohistochemical analysis reveals TENM1 localization along neuronal membranes and synaptic sites, while western blot identifies multiple high molecular weight bands reflecting post-translationally modified isoforms. The TENM1 antibody therefore serves as a versatile reagent for studies in neurobiology and tumor progression. NSJ Bioreagents provides this antibody validated for its applications, enabling detailed investigation of Teneurin 1-mediated cellular communication.

UniProt: Q9UKZ4

Pathways: Regulation of Actin Filament Polymerization