DRD5 Antikörper (AA 1-477)

Produktnummer ABIN7869397

Der Kaninchen Polyklonal anti-DRD5 Antikörper (ABIN7869397) detektiert spezifisch DRD5 in WB, ELISA und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für DRD5 Antikörper (AA 1-477) (ABIN7869397)

Target: DRD5 (Dopamine Receptor D5 (DRD5))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DRD5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-DRD5 Antikörper

Bindungsspezifität: AA 1-477

Verwendungszweck: DRD5 Antibody / Dopamine receptor D5

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human DRD5 recombinant protein (Position: M1-H477) was used as the immunogen for the DRD5 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the DRD5 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the DRD5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu DRD5

Target: DRD5 (Dopamine Receptor D5 (DRD5))

Andere Bezeichnung: DRD5

Hintergrund: DRD5 antibody detects Dopamine receptor D5, encoded by the DRD5 gene on chromosome 4p15.33. DRD5 antibody is commonly used in neuroscience, pharmacology, and psychiatry research. DRD5 is a G protein-coupled receptor (GPCR) belonging to the D1-like dopamine receptor family. It couples to stimulatory G proteins (Gs), leading to activation of adenylate cyclase and increased intracellular cAMP. DRD5 plays key roles in regulating movement, reward processing, learning, and behavior. Expression is enriched in the brain, particularly in limbic regions and the hippocampus, but it is also present in peripheral tissues including kidney and vasculature.

Structurally, DRD5 is a seven-transmembrane GPCR with extracellular ligand-binding loops and intracellular domains that couple to G proteins. Compared with DRD1, DRD5 has higher affinity for dopamine and distinct distribution patterns. Post-translational modifications, including phosphorylation and palmitoylation, modulate receptor trafficking and signaling. Isoforms generated by alternative splicing may alter receptor activity in tissue-specific contexts.

Functionally, DRD5 regulates neuronal excitability, synaptic plasticity, and memory formation. In hippocampal neurons, DRD5 activation enhances long-term potentiation, a process underlying learning. In striatal circuits, it integrates with DRD1 to regulate locomotion and motor control. Outside the CNS, DRD5 influences renal sodium excretion and vascular tone, linking dopamine signaling to blood pressure regulation. Researchers use DRD5 antibody to study dopaminergic signaling, neurological disease, and receptor pharmacology.

Clinically, DRD5 has been associated with neurological and psychiatric disorders, including schizophrenia, attention deficit hyperactivity disorder, and Parkinson's disease. Polymorphisms in DRD5 contribute to variability in behavioral traits and drug responses. Studies also implicate DRD5 in hypertension due to its renal functions. Because dopamine receptors are major therapeutic targets, DRD5 is under investigation for its contribution to dopaminergic drug responses. NSJ Bioreagents supplies DRD5 antibody as a validated tool for neuroscience and pharmacology research.

Experimentally, DRD5 antibody is used in western blotting to detect the ~53 kDa receptor, in immunofluorescence microscopy to study subcellular localization, and in immunohistochemistry to map receptor distribution in brain and peripheral tissues. Co-immunoprecipitation with DRD5 antibody helps identify interacting partners and signaling complexes.

UniProt: P21918

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity