ODC1 Antikörper (AA 1-450)

Produktnummer ABIN7869376

Der Kaninchen Polyklonal anti-ODC1 Antikörper (ABIN7869376) detektiert spezifisch ODC1 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte und Maus.

Kurzübersicht für ODC1 Antikörper (AA 1-450) (ABIN7869376)

Target: ODC1 (Ornithine Decarboxylase 1 (ODC1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ODC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-ODC1 Antikörper

Bindungsspezifität: AA 1-450

Verwendungszweck: ODC1 Antibody / Ornithine decarboxylase 1

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human ODC1 recombinant protein (Position: M1-H450) was used as the immunogen for the ODC1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the ODC1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the ODC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu ODC1

Target: ODC1 (Ornithine Decarboxylase 1 (ODC1))

Andere Bezeichnung: ODC1

Hintergrund: ODC1 antibody detects Ornithine decarboxylase 1, encoded by the ODC1 gene on chromosome 2p25.1. ODC1 antibody is widely used in research on polyamine metabolism, cell growth, and cancer biology. Ornithine decarboxylase 1 is the rate-limiting enzyme in polyamine biosynthesis, catalyzing the decarboxylation of ornithine to produce putrescine. Polyamines are essential for DNA stabilization, transcription, and cell proliferation. Expression of ODC1 is tightly regulated by growth factors, hormones, and oncogenes, with high activity in rapidly dividing cells.

Structurally, ODC1 is a homodimeric enzyme of ~53 kDa per subunit, containing pyridoxal phosphate (PLP)-dependent catalytic sites. The enzyme undergoes rapid turnover regulated by antizyme-mediated degradation, ensuring tight control of polyamine levels. Conserved structural motifs ensure catalytic efficiency across species.

Functionally, ODC1 is critical for cell proliferation and tissue growth. By generating putrescine, it supports synthesis of spermidine and spermine, polyamines required for nucleic acid function and chromatin organization. Overexpression of ODC1 enhances proliferation and tumorigenesis, while inhibition by difluoromethylornithine (DFMO) blocks polyamine synthesis and reduces tumor growth. Researchers use ODC1 antibody to investigate polyamine metabolism, oncogene signaling, and therapeutic interventions.

Clinically, ODC1 overexpression is observed in many cancers, including colon, prostate, and neuroblastoma. It is regulated by oncogenes such as MYC, linking ODC1 to tumorigenesis. Genetic polymorphisms in ODC1 influence cancer risk and response to chemoprevention strategies involving polyamine inhibitors. Beyond oncology, ODC1 has roles in wound healing, immune responses, and neurological function. NSJ Bioreagents supplies ODC1 antibody to support cancer research, metabolism studies, and therapeutic development.

Experimentally, ODC1 antibody is applied in western blotting to detect the ~53 kDa protein, in immunohistochemistry to assess expression in tumors, and in immunofluorescence microscopy to study subcellular distribution. Enzymatic assays combined with ODC1 antibody help correlate expression with catalytic activity.

UniProt: P11926