Sphingomyelin Synthase 1 Antikörper (AA 1-413)

Produktnummer ABIN7869329

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Sphingomyelin Synthase 1 in WB, ELISA und FACS. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für Sphingomyelin Synthase 1 Antikörper (AA 1-413) (ABIN7869329)

Target: Sphingomyelin Synthase 1 (SGMS1)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Sphingomyelin Synthase 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-Sphingomyelin Synthase 1 Antikörper

Bindungsspezifität: AA 1-413

Verwendungszweck: SGMS1 Antibody / Sphingomyelin synthase 1

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human SGMS1 recombinant protein (Position: M1-T413) was used as the immunogen for the SGMS1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SGMS1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the SGMS1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Sphingomyelin Synthase 1

Target: Sphingomyelin Synthase 1 (SGMS1)

Andere Bezeichnung: SGMS1

Hintergrund: SGMS1 antibody detects Sphingomyelin synthase 1, encoded by the SGMS1 gene. Sphingomyelin synthase 1 is a plasma membrane-associated enzyme that catalyzes the conversion of ceramide and phosphatidylcholine into sphingomyelin and diacylglycerol. SGMS1 antibody provides researchers with a tool for studying sphingolipid metabolism, membrane biology, and signaling processes linked to cell survival and apoptosis.

Sphingomyelin synthase 1 belongs to the sphingomyelin synthase family of enzymes and is localized at the plasma membrane and Golgi apparatus. Research using SGMS1 antibody has shown that the enzyme regulates levels of sphingomyelin, a major structural component of membranes, while simultaneously producing diacylglycerol, a second messenger that activates protein kinase C. This dual metabolic and signaling role highlights SGMS1 as a central regulator of lipid homeostasis and cell signaling pathways.

Studies with SGMS1 antibody have demonstrated that disruption of SGMS1 alters plasma membrane composition, impairing lipid raft formation and receptor signaling. Deficiency in SGMS1 leads to accumulation of ceramide, which promotes apoptosis, while excess activity favors cell survival and proliferation. This balance underscores the importance of SGMS1 in processes ranging from development to disease.

Dysregulation of Sphingomyelin synthase 1 has been associated with cancer, metabolic disease, and immune dysfunction. Research using SGMS1 antibody has shown that high SGMS1 activity supports tumor cell survival, while inhibition sensitizes cells to apoptosis-inducing agents. In immune biology, SGMS1 influences T cell receptor signaling and cytokine release. These findings make SGMS1 both a biomarker and a potential therapeutic target.

SGMS1 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting quantifies expression in cell lines and tissues, immunohistochemistry demonstrates expression in tumors and metabolic tissues, and immunofluorescence highlights subcellular distribution. These approaches make SGMS1 antibody indispensable for lipid biology research.

By supplying validated SGMS1 antibody reagents, NSJ Bioreagents supports studies into sphingolipid metabolism, apoptosis, and disease. Detection of Sphingomyelin synthase 1 provides researchers with insight into how lipid enzymes regulate both membrane composition and signaling.

UniProt: Q86VZ5

Pathways: Cellular Response to Molecule of Bacterial Origin