FOXI1 Antikörper (AA 1-378)

Produktnummer ABIN7869272

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch FOXI1 in WB, ELISA, IF, FACS und ICC. Es zeigt Reaktivität gegenüber Proben von Human und Ratte.

Kurzübersicht für FOXI1 Antikörper (AA 1-378) (ABIN7869272)

Target: FOXI1 (Forkhead Box I1 (FOXI1))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FOXI1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Produktdetails anti-FOXI1 Antikörper

Bindungsspezifität: AA 1-378

Verwendungszweck: FOXI1 Antibody / Forkhead box protein I1

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human FOXI1 recombinant protein (Position: M1-V378) was used as the immunogen for the FOXI1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the FOXI1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the FOXI1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu FOXI1

Target: FOXI1 (Forkhead Box I1 (FOXI1))

Andere Bezeichnung: FOXI1

Hintergrund: FOXI1 antibody targets Forkhead box protein I1, a member of the FOX family of transcription factors characterized by a conserved forkhead or 'winged helix' DNA-binding domain. The FOXI1 gene, located on chromosome 5q35.1, encodes a nuclear transcription factor that regulates ion transport and epithelial differentiation, particularly in the inner ear, kidney, and epididymis. FOXI1 controls expression of genes involved in acid-base balance and fluid homeostasis, including the vacuolar H+-ATPase subunit and pendrin (SLC26A4), a chloride/bicarbonate exchanger essential for maintaining luminal pH .

Structurally, FOXI1 contains a 110-amino acid forkhead domain that interacts with specific DNA motifs to modulate transcriptional activity. It functions as a transcriptional activator for genes expressed in intercalated cells of the distal nephron and cochlear epithelial cells. In the inner ear, FOXI1 contributes to endolymphatic ion transport and hearing development. In the kidney, loss of FOXI1 disrupts acid secretion, resulting in distal renal tubular acidosis (dRTA). Genetic mutations in FOXI1 have been linked to autosomal recessive dRTA and sensorineural hearing loss, demonstrating its dual role in renal and auditory physiology.

FOXI1 also participates in epithelial polarity regulation and may influence Wnt and Notch signaling pathways during organogenesis. Dysregulation of FOXI1 expression has been reported in certain cancers, where it may contribute to altered epithelial transport and cell differentiation. Functional studies suggest FOXI1 acts as a transcriptional regulator for ion transport proteins and can modulate developmental genes associated with morphogenesis of the ear and kidney.

Immunohistochemical staining using FOXI1 antibody reveals nuclear localization in renal intercalated cells, cochlear epithelium, and reproductive tissues. FOXI1 antibody from NSJ Bioreagents provides an essential reagent for research in transcriptional regulation, epithelial physiology, and hereditary renal and auditory disorders.

UniProt: Q12951