IFI44 Antikörper (AA 1-370)

Produktnummer ABIN7869263

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch IFI44 in WB, ELISA und FACS. Es zeigt Reaktivität gegenüber Proben von Maus und Ratte.

Kurzübersicht für IFI44 Antikörper (AA 1-370) (ABIN7869263)

Target: IFI44 (Interferon-Induced Protein 44 (IFI44))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IFI44 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-IFI44 Antikörper

Bindungsspezifität: AA 1-370

Verwendungszweck: IFI44 Antibody / Interferon induced protein 44

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived mouse IFI44 recombinant protein (Position: M1-H370) was used as the immunogen for the IFI44 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the IFI44 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the IFI44 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu IFI44

Target: IFI44 (Interferon-Induced Protein 44 (IFI44))

Andere Bezeichnung: IFI44

Hintergrund: IFI44 antibody detects Interferon-induced protein 44, encoded by the IFI44 gene on chromosome 1p31.1. IFI44 antibody is commonly used in immunology, antiviral, and autoimmune disease research. IFI44 is an interferon-stimulated gene product induced by type I interferons and viral infection. It contributes to the host antiviral defense response and is a biomarker of interferon pathway activation.

Structurally, IFI44 is a ~50 kDa protein with coiled-coil domains but lacks known catalytic motifs. It localizes predominantly to the cytoplasm, with potential mitochondrial and cytoskeletal associations. Its structure suggests a role as a scaffold or regulator rather than an enzyme.

Functionally, IFI44 is strongly induced by viral infections including influenza, hepatitis C virus, and SARS-CoV. It enhances innate immune responses, possibly by modulating cytoskeletal dynamics or mitochondrial function. Researchers use IFI44 antibody to study interferon responses, viral pathogenesis, and autoimmune disease mechanisms.

Clinically, IFI44 is elevated in autoimmune diseases such as systemic lupus erythematosus and dermatomyositis, where interferon signatures correlate with disease severity. It has been proposed as a diagnostic biomarker for interferon-driven conditions. IFI44 polymorphisms may also influence susceptibility to viral infections. NSJ Bioreagents provides IFI44 antibody to support immunology and infectious disease research.

Experimentally, IFI44 antibody is used in western blotting to detect the ~50 kDa protein, in immunohistochemistry to assess tissue expression, and in immunofluorescence to study cytoplasmic distribution. Transcriptomic studies often pair IFI44 expression with IFI44L to define interferon response signatures, and IFI44 antibody provides the protein-level validation.

UniProt: Q8BV66