Phospholamban Antikörper (AA 1-36)

Produktnummer ABIN7869249

Der Kaninchen Polyklonal anti-Phospholamban Antikörper wird verwendet zum Nachweis von Phospholamban in Proben von Human, Ratte und Maus. Er wurde validiert für WB, ELISA und IHC (p).

Kurzübersicht für Phospholamban Antikörper (AA 1-36) (ABIN7869249)

Target: Phospholamban (PLN)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Phospholamban Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Phospholamban Antikörper

Bindungsspezifität: AA 1-36

Verwendungszweck: PLB Antibody / Phospholamban / PLN

Aufreinigung: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids M1-C36) was used as the immunogen for the PLB antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PLB antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the PLB antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Phospholamban

Target: Phospholamban (PLN)

Andere Bezeichnung: PLB

Hintergrund: Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca2+ pump in cardiac muscle and skeletal muscle cells. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. Phospholamban is also expressed in slow-twitch skeletal muscle and some smooth muscle cells. It is observed that human ventricle and quadriceps displayed high levels of phospholamban transcripts and proteins, with markedly lower expression observed in smooth muscles, while the right atrium also expressed low levels of phospholamban. The structure of the human phospholamban gene closely resembles that reported for chicken, rabbit, rat, and mouse. Comparison of the human to other mammalian phospholamban genes indicated a marked conservation of sequence for at least 217 bp upstream of the transcription start site.

UniProt: P26678

Pathways: Negative Regulation of Transporter Activity