PHYHIPL Antikörper (AA 1-336)

Produktnummer ABIN7869211

Der Kaninchen Polyklonal anti-PHYHIPL Antikörper (ABIN7869211) detektiert spezifisch PHYHIPL in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für PHYHIPL Antikörper (AA 1-336) (ABIN7869211)

Target: PHYHIPL (Phytanoyl-CoA 2-Hydroxylase Interacting Protein-Like (PHYHIPL))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PHYHIPL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-PHYHIPL Antikörper

Bindungsspezifität: AA 1-336

Verwendungszweck: PHYHIPL Antibody / Phytanoyl-CoA hydroxylase-interacting protein-like

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human PHYHIPL recombinant protein (Position: M1-D336) was used as the immunogen for the PHYHIPL antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PHYHIPL antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the PHYHIPL antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu PHYHIPL

Target: PHYHIPL (Phytanoyl-CoA 2-Hydroxylase Interacting Protein-Like (PHYHIPL))

Andere Bezeichnung: PHYHIPL

Hintergrund: PHYHIPL antibody detects Phytanoyl-CoA hydroxylase-interacting protein-like, a poorly characterized cytoplasmic protein implicated in neuronal signaling and lipid metabolism. Although its precise biochemical function remains under investigation, PHYHIPL is thought to participate in protein-protein interactions related to peroxisomal fatty acid metabolism and neurodevelopmental regulation. The PHYHIPL antibody is used in neuroscience and metabolic studies to explore neuronal protein networks and lipid homeostasis.

PHYHIPL is encoded by the PHYHIPL gene located on human chromosome 10p12.2. The protein is approximately 148 amino acids long and shows sequence similarity to PHYHIP, which interacts with phytanoyl-CoA hydroxylase, an enzyme involved in alpha-oxidation of branched-chain fatty acids. PHYHIPL is expressed in the brain, liver, and heart, suggesting a broader metabolic role than its paralog.

The PHYHIPL antibody detects a 16 kilodalton protein by western blot and displays diffuse cytoplasmic staining under immunofluorescence microscopy. Although the functional data are limited, PHYHIPL has been linked to neuronal differentiation, axonal growth, and synaptic organization through proteomic analyses. It may serve as an adaptor or scaffolding molecule connecting lipid metabolism enzymes with cytoskeletal or signaling components.

Transcriptomic studies reveal that PHYHIPL expression is enriched in developing neural tissues and reduced in neurodegenerative diseases, indicating potential roles in brain maturation and protection. It has also been identified as a candidate biomarker in studies of metabolic syndromes and cardiovascular disease due to altered expression in lipid-related pathways.

Because PHYHIPL likely integrates metabolic and neuronal processes, it serves as a promising research target for understanding how lipid metabolism supports neural function. NSJ Bioreagents provides a validated PHYHIPL antibody optimized for its applications, supporting research into lipid regulation, brain development, and cellular metabolism.

UniProt: Q96FC7