DREAM Antikörper (AA 1-30)

Produktnummer ABIN7869096

Der Kaninchen Polyklonal anti-DREAM Antikörper wird verwendet zum Nachweis von DREAM in Proben von Human und Maus. Er wurde validiert für WB, IF und IHC (p).

Kurzübersicht für DREAM Antikörper (AA 1-30) (ABIN7869096)

Target: DREAM (KCNIP3) (Kv Channel Interacting Protein 3, Calsenilin (KCNIP3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DREAM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-DREAM Antikörper

Bindungsspezifität: AA 1-30

Verwendungszweck: KCNIP3 Antibody / Calsenilin / KChIP3

Aufreinigung: Purified

Immunogen: A portion of amino acids 1-30 from the human protein was used as the immunogen for the KCNIP3 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the KCNIP3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the KCNIP3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu DREAM

Target: DREAM (KCNIP3) (Kv Channel Interacting Protein 3, Calsenilin (KCNIP3))

Andere Bezeichnung: KCNIP3

Hintergrund: KChIP3 is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein is also shown to function as a calcium-regulated transcriptional repressor, and to interact with presenilins. Mutations in the presenilin genes have been implicated in Alzheimer's disease. Due to utilization of an alternate in-frame translation start codon, the gene for this protein encodes two isoforms with different sizes.

UniProt: Q9Y2W7