DUSP10 Antikörper (AA 1-30)

Produktnummer ABIN7869087

Der Kaninchen Polyklonal anti-DUSP10 Antikörper wird verwendet zum Nachweis von DUSP10 in Proben von Human und Maus. Er wurde validiert für WB und IHC (p).

Kurzübersicht für DUSP10 Antikörper (AA 1-30) (ABIN7869087)

Target: DUSP10 (Dual Specificity Phosphatase 10 (DUSP10))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DUSP10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-DUSP10 Antikörper

Bindungsspezifität: AA 1-30

Verwendungszweck: Dual specificity protein phosphatase 10 Antibody / DUSP10

Aufreinigung: Purified

Immunogen: A portion of amino acids 1-30 from the human protein was used as the immunogen for the Dual specificity protein phosphatase 10 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the Dual specificity protein phosphatase 10 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Dual specificity protein phosphatase 10 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu DUSP10

Target: DUSP10 (Dual Specificity Phosphatase 10 (DUSP10))

Andere Bezeichnung: Dual specificity protein phosphatase 10

Hintergrund: Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP10 binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique, it is evenly distributed in both the cytoplasm and the nucleus. The protein is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli.

UniProt: Q9Y6W6