NQO1 Antikörper (AA 1-274)

Produktnummer ABIN7869027

Der Kaninchen Polyklonal anti-NQO1 Antikörper wird verwendet zum Nachweis von NQO1 in Proben von Human. Er wurde validiert für WB, IF, FACS und IHC (p).

Kurzübersicht für NQO1 Antikörper (AA 1-274) (ABIN7869027)

Target: NQO1 (NAD(P)H Dehydrogenase, Quinone 1 (NQO1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NQO1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-NQO1 Antikörper

Bindungsspezifität: AA 1-274

Verwendungszweck: NQO1 Antibody

Aufreinigung: Affinity purified

Immunogen: Amino acids M1-K274 from the human protein were used as the immunogen for the NQO1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the NQO1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the NQO1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu NQO1

Target: NQO1 (NAD(P)H Dehydrogenase, Quinone 1 (NQO1))

Andere Bezeichnung: NQO1

Hintergrund: NAD(P)H:quinone oxidoreductase 1 (NQO1) is a cytosolic flavoprotein that plays a central role in cellular defense against oxidative stress. As a 2-electron reductase, NQO1 catalyzes the reduction of quinones to hydroquinones, thereby preventing the formation of reactive oxygen species through redox cycling. This detoxifying activity contributes to the maintenance of redox homeostasis and protection of cells from oxidative damage. Research with an NQO1 antibody has provided valuable insights into its functions in normal physiology and disease.

NQO1 expression is regulated by the Nrf2 pathway and is upregulated under stress conditions as part of the antioxidant response. Elevated levels of this enzyme have been reported in various cancers, suggesting a dual role in both cytoprotection and tumor progression. Studies using an NQO1 antibody have linked the protein to drug metabolism, chemoresistance, and its potential as a therapeutic target. Beyond oncology, NQO1 has been studied in relation to cardiovascular disease, neurodegeneration, and aging.

The enzyme also stabilizes certain proteins by protecting them from proteasomal degradation, further highlighting its regulatory importance in cell survival pathways. Given these diverse roles, the use of an NQO1 antibody is valuable for detecting protein expression across tissues, evaluating stress responses, and exploring disease-specific alterations. NSJ Bioreagents offers high-quality NQO1 antibody reagents designed for applications including western blot, immunohistochemistry, and immunofluorescence, enabling researchers to further define the biological significance of this multifunctional protein.

UniProt: P15559