MIOX Antikörper (AA 1-266)

Produktnummer ABIN7869006

Der Kaninchen Polyklonal anti-MIOX Antikörper wird verwendet zum Nachweis von MIOX in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA, IHC und FACS.

Kurzübersicht für MIOX Antikörper (AA 1-266) (ABIN7869006)

Target: MIOX (Myo-Inositol Oxygenase (MIOX))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MIOX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Produktdetails anti-MIOX Antikörper

Bindungsspezifität: AA 1-266

Verwendungszweck: MIOX Antibody / Myo-inositol oxygenase

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human MIOX recombinant protein (Position: M1-K266) was used as the immunogen for the MIOX antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the MIOX antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the MIOX antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu MIOX

Target: MIOX (Myo-Inositol Oxygenase (MIOX))

Andere Bezeichnung: MIOX

Hintergrund: MIOX antibody detects Myo-inositol oxygenase, encoded by the MIOX gene. Myo-inositol oxygenase is an enzyme located in the renal cortex that catalyzes the first committed step in the myo-inositol catabolism pathway. MIOX antibody provides researchers with a specialized reagent for studying renal metabolism, inositol regulation, and diabetic kidney disease.

Myo-inositol oxygenase belongs to the sugar oxygenase family of non-heme iron enzymes. Research using MIOX antibody has shown that it catalyzes the conversion of myo-inositol to D-glucuronic acid, a pathway that links inositol metabolism to glucuronidation and detoxification. Its restricted expression in the kidney makes MIOX a tissue-specific metabolic regulator.

Studies with MIOX antibody have revealed that overexpression of MIOX occurs in diabetic nephropathy, where it contributes to oxidative stress and tubular injury. Elevated activity leads to increased generation of reactive oxygen species, impairing renal function. These findings highlight its role as both a metabolic enzyme and a contributor to disease progression in diabetes.

Dysregulation of Myo-inositol oxygenase has also been implicated in kidney injury, fibrosis, and metabolic disorders. Research using MIOX antibody has shown that suppression of MIOX protects against oxidative stress-induced renal injury, suggesting therapeutic potential in chronic kidney disease. Beyond renal biology, MIOX may contribute to systemic regulation of inositol levels and metabolic pathways.

MIOX antibody is widely applied in western blotting, immunohistochemistry, and enzymatic studies. Western blotting quantifies expression in renal tissue, immunohistochemistry highlights tubular expression in kidney cortex, and enzymatic assays confirm catalytic activity. These applications make MIOX antibody indispensable for renal metabolism research.

By supplying validated MIOX antibody reagents, NSJ Bioreagents supports studies into kidney metabolism, diabetes, and oxidative stress. Detection of Myo-inositol oxygenase provides researchers with insight into how inositol catabolism contributes to renal physiology and pathology.

UniProt: Q9UGB7

Pathways: Inositol Metabolic Process