GTPase, IMAP Family Member 1 (GIMAP1) (AA 1-238) Antikörper

Produktnummer ABIN7868892

Der Kaninchen Polyklonal anti-GTPase, IMAP Family Member 1 Antikörper wird verwendet zum Nachweis von GTPase, IMAP Family Member 1 in Proben von Human. Er wurde validiert für WB, ELISA und FACS.

Kurzübersicht für GTPase, IMAP Family Member 1 (GIMAP1) (AA 1-238) Antikörper (ABIN7868892)

Target: GTPase, IMAP Family Member 1 (GIMAP1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails

Bindungsspezifität: AA 1-238

Verwendungszweck: GIMAP1 Antibody / GTPase IMAP family member 1

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human GIMAP1 recombinant protein (Position: M1-E238) was used as the immunogen for the GIMAP1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the GIMAP1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the GIMAP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Antigendetails

Target: GTPase, IMAP Family Member 1 (GIMAP1)

Andere Bezeichnung: GIMAP1

Hintergrund: GIMAP1 antibody detects GTPase IMAP family member 1, a small GTP-binding protein involved in lymphocyte survival and immune regulation. The UniProt recommended name is GTPase IMAP family member 1 (GIMAP1). This protein belongs to the GIMAP (GTPase of immunity-associated proteins) family, which participates in T-cell development, apoptosis resistance, and mitochondrial homeostasis within immune cells.

Functionally, GIMAP1 antibody identifies a 320-amino-acid cytoplasmic and mitochondrial membrane-associated GTPase. GIMAP1 regulates cell survival by maintaining mitochondrial integrity and preventing apoptotic signaling during lymphocyte maturation. It interacts with other GIMAP family members and BCL2-related proteins to modulate intrinsic apoptosis pathways. GIMAP1 expression is induced during T-cell activation and may help coordinate metabolic adaptation and survival under stress conditions.

The GIMAP1 gene is located on chromosome 7q36.1 and is expressed predominantly in thymus, spleen, and peripheral lymphocytes. Its expression pattern mirrors that of immune cell differentiation markers, underscoring its role in adaptive immunity. GIMAP1 acts as a key survival regulator in the transition of T-cells from double-positive to single-positive stages in the thymus.

Pathologically, GIMAP1 dysregulation has been linked to autoimmune disorders and lymphoid malignancies. Loss of function leads to increased apoptosis of lymphocytes and immunodeficiency, while overexpression contributes to T-cell survival in leukemia. Research using GIMAP1 antibody supports studies in immunology, cell survival pathways, and mitochondrial regulation in immune cells.

GIMAP1 antibody is validated for western blotting, immunofluorescence, and flow cytometry to detect small GTPases involved in immune cell regulation. NSJ Bioreagents provides GIMAP1 antibody reagents optimized for research in lymphocyte biology, apoptosis resistance, and mitochondrial signaling.

Structurally, GTPase IMAP family member 1 contains conserved GTP-binding motifs typical of small GTPases, including the P-loop, switch I, and switch II regions that mediate nucleotide binding and hydrolysis. Its membrane association and GTP-dependent conformational changes regulate interactions with mitochondrial and cytoskeletal components. This antibody enables detailed analysis of GIMAP1's role in immune homeostasis and cell survival signaling.

UniProt: Q8WWP7