THYN1 Antikörper (AA 1-225)

Produktnummer ABIN7868862

Der Kaninchen Polyklonal anti-THYN1 Antikörper wird verwendet zum Nachweis von THYN1 in Proben von Human. Er wurde validiert für WB, ELISA, IP, ICC, IF und FACS.

Kurzübersicht für THYN1 Antikörper (AA 1-225) (ABIN7868862)

Target: THYN1 (Thymocyte Nuclear Protein 1 (THYN1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser THYN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-THYN1 Antikörper

Bindungsspezifität: AA 1-225

Verwendungszweck: THYN1 Antibody / Thymocyte nuclear protein 1

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human THYN1 recombinant protein (Position: M1-S225) was used as the immunogen for the THYN1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the THYN1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the THYN1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu THYN1

Target: THYN1 (Thymocyte Nuclear Protein 1 (THYN1))

Andere Bezeichnung: THYN1

Hintergrund: THYN1 antibody detects Thymocyte nuclear protein 1, a nuclear DNA-binding protein that plays a role in apoptosis regulation, lymphocyte differentiation, and chromatin organization. Encoded by the THYN1 gene on chromosome 11q25, this evolutionarily conserved protein is predominantly expressed in thymocytes and lymphoid tissues, where it contributes to T-cell maturation and apoptotic signaling. THYN1 is also found in other proliferative cell types, indicating a broader role in cell cycle regulation and genomic stability.

Structurally, Thymocyte nuclear protein 1 is a 225-amino-acid protein of approximately 26 kilodaltons that localizes to the nucleus. It contains multiple lysine and arginine-rich regions that facilitate DNA interaction and chromatin association, as well as nuclear localization sequences that ensure retention within the nucleus. Its precise molecular function remains under study, but evidence suggests that THYN1 participates in apoptotic chromatin condensation and transcriptional control during cell stress and differentiation.

The THYN1 antibody is widely used in immunology, apoptosis, and hematopoiesis research to study nuclear regulation of T-cell development and programmed cell death. Western blot analysis detects a band at approximately 28 kilodaltons corresponding to THYN1, while immunofluorescence demonstrates nuclear punctate staining consistent with chromatin association. This antibody is a valuable tool for understanding nuclear protein dynamics in immune cell differentiation and apoptosis signaling.

Functionally, THYN1 has been linked to regulation of the apoptotic pathway through interactions with caspase-dependent DNA fragmentation processes. Its expression is highest in thymocytes undergoing negative selection, suggesting a role in eliminating autoreactive T-cells. Beyond immune regulation, THYN1 may contribute to chromatin remodeling and transcriptional repression during stress-induced cell cycle arrest. Dysregulation of THYN1 has been associated with cancer cell survival and abnormal immune function, underscoring its potential role in tumor immunology and apoptosis resistance. The THYN1 antibody supports investigations into nuclear apoptosis mechanisms and T-cell homeostasis. NSJ Bioreagents provides this antibody validated for its applications, ensuring consistent performance in nuclear and immune biology research.

UniProt: Q9P016