SURF6 Antikörper (AA 1-216)

Produktnummer ABIN7868836

Der Kaninchen Polyklonal anti-SURF6 Antikörper (ABIN7868836) detektiert spezifisch SURF6 in WB, ELISA, ICC und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für SURF6 Antikörper (AA 1-216) (ABIN7868836)

Target: SURF6 (Surfeit 6 (SURF6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SURF6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Produktdetails anti-SURF6 Antikörper

Bindungsspezifität: AA 1-216

Verwendungszweck: SURF6 Antibody / Surfeit locus protein 6

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human SURF6 recombinant protein (Position: M1-R216) was used as the immunogen for the SURF6 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SURF6 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the SURF6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu SURF6

Target: SURF6 (Surfeit 6 (SURF6))

Andere Bezeichnung: SURF6

Hintergrund: SURF6 antibody detects Surfeit locus protein 6, a nucleolar protein involved in ribosome biogenesis and pre-rRNA processing. The UniProt recommended name is Surfeit locus protein 6 (SURF6). This evolutionarily conserved nucleolar factor functions as a scaffold for ribonucleoprotein complex assembly during early steps of ribosome formation.

Functionally, SURF6 antibody identifies a 360-amino-acid protein localized to the granular component of the nucleolus, where it associates with pre-rRNA transcripts and ribosomal assembly intermediates. SURF6 interacts with fibrillarin and nucleolin, facilitating pre-rRNA maturation and 60S ribosomal subunit formation. Its RNA-binding capacity and nucleolar localization signal make it an essential factor for ribosome production and nucleolar organization.

The SURF6 gene is located on chromosome 9q34.2 and is expressed ubiquitously, with high levels in proliferating and metabolically active cells. Expression correlates with cellular growth rate, reflecting its role in ribosome synthesis and protein translation capacity.

Pathologically, dysregulation of SURF6 expression has been linked to oncogenesis and stress response modulation. Overexpression is observed in various cancers and is associated with increased ribosome biogenesis and cell proliferation. Conversely, depletion of SURF6 triggers nucleolar stress, p53 activation, and growth arrest. Research using SURF6 antibody supports studies in ribosome assembly, nucleolar dynamics, and cancer biology.

SURF6 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect nucleolar proteins. NSJ Bioreagents provides SURF6 antibody reagents optimized for studies in ribosomal biogenesis, nucleolar organization, and cellular stress response.

Structurally, Surfeit locus protein 6 contains arginine-rich motifs that mediate RNA binding and multiple acidic stretches that promote protein-protein interactions within the nucleolus. Its modular domains contribute to the architecture of the ribosomal assembly machinery. This antibody facilitates exploration of SURF6's function in nucleolar integrity and ribosome maturation.

UniProt: O75683

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly