T-Bet Antikörper (AA 1-200)

Produktnummer ABIN7868765

Dieser Maus Monoklonal Antikörper detektiert spezifisch T-Bet in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für T-Bet Antikörper (AA 1-200) (ABIN7868765)

Target: T-Bet

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser T-Bet Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: TBX21-6724

Produktdetails anti-T-Bet Antikörper

Bindungsspezifität: AA 1-200

Verwendungszweck: TBX21 Antibody / T-bet

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the TBX21 antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TBX21 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the TBX21 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu T-Bet

Target: T-Bet

Andere Bezeichnung: TBX21

Hintergrund: T helper (Th) lymphocytes differentiate into two unique subsets, Th1 and Th2, which differ both in function and in the cytokines they secrete. Th1 and Th2 cytokines promote the growth and differentiation of their subset, and inhibit the growth and differentiation of the opposing subset. T-bet (T-box expressed in T cells) is a Th1-specific T-box transcription factor that controls the expression of the Th1 cytokine, IFN-g. T-bet also converts effector Th2 cells into the opposing Th1 subset. T-bet is selectively expressed in Th1 cells. The level of T-bet expression is increased by signals mediated by the T cell receptor (TCR). IL-12 also induces an increase in the level of T-bet. T-bet was originally isolated from nuclear extracts of resting and PMA/ionomycin-activated AE7 cells. It is expressed in low levels in AE7 cells, and in increased levels in stimulated AE7.

UniProt: Q9UL17