Neurogenin 3 Antikörper (AA 1-200)

Produktnummer ABIN7868676

Der Maus Monoklonal anti-Neurogenin 3 Antikörper wird verwendet zum Nachweis von Neurogenin 3 in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für Neurogenin 3 Antikörper (AA 1-200) (ABIN7868676)

Target: Neurogenin 3 (NEUROG3)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Neurogenin 3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: NGN3-1808

Produktdetails anti-Neurogenin 3 Antikörper

Bindungsspezifität: AA 1-200

Verwendungszweck: Neurogenin 3 Antibody (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein (within amino acids 1-200) from the human protein was used as the immunogen for the Neurogenin 3 antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Neurogenin 3 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Neurogenin 3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu Neurogenin 3

Target: Neurogenin 3 (NEUROG3)

Andere Bezeichnung: Neurogenin 3

Hintergrund: This antigen is a transcription factor that interacts with NKX2-2 to regulation transcription of NEUROD1. The neurogenin family of proteins belongs to the basic helix-loop-helix (bHLH) superfamily and consists of Neurogenin 1, Neurogenin 2 and Neurogenin 3 (also designated ngn3). bHLH members are transcriptional regulators that determine cell fate. Neurogenin 3 is expressed in discrete regions of developing neurons and in the embryonic pancreatic islets of Langerhans. HNF-6 (hepatocyte nuclear factor 6) acts as a positive regulator of Neurogenin 3 by binding to and stimulating the neurogenin gene promoter. Neurogenin 3 is involved in the initial differentiation of the four islets cell types, while a network of transcription factors, including Hlxb9, Isl1, NeuroD, Nkx-2.2, Nkx-6.4, Pax-4, Pax-6, PDX-1 and Mash1, are required for final differentiation. Neurogenin 3 acts upstream of NeuroD in a bHLH cascade. Neurogenin 3 activates the expression of NeuroD at the onset of islet cell differentiation through box sequences E1 and E3 in the NeuroD promoter.

UniProt: Q9Y4Z2